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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
Wc1 And Tcr Interactions For Γδ T Cell Activation, Alexandria Gillespie
Wc1 And Tcr Interactions For Γδ T Cell Activation, Alexandria Gillespie
Doctoral Dissertations
Major subpopulations of gamma delta T cells within ruminant and pigs are defined by expression of WC1, a hybrid pattern recognition receptor/co-receptor to the T cell receptor (TCR). It is known that when WC1 is knocked down cells fail to respond. Showing that WC1 plays an active role in the stimulation of bovine gamma delta T cells. Here we explored the spatio-temporal dynamics of WC1 and TCR interaction using imaging flow cytometry and stochastic optical reconstruction microscopy. We found that in quiescent gamma delta T cells both WC1 and TCR existed in separate protein domains (protein islands) but after activation …
Regulation Of B Cell Response To Respiratory Viruses, Aarthi Sundararajan
Regulation Of B Cell Response To Respiratory Viruses, Aarthi Sundararajan
Doctoral Dissertations
Viruses replicating in the respiratory tract (RT) triggers a wide- range of cytokines and chemokines that have antiviral and pro-inflammatory features, instigating an efficient virus- specific B and T cell response that aids in virus- clearance. The majority of antibody secreting cells (ASCs) localizing in the upper RT secrete IgA that can effectively neutralize viruses. In addition, elements of B cell memory are generated that can provide protection from re-infection. Studies examining these aspects, following murine gammaherpesvirus 68 (MHV-68) infection comprise chapter 2 of the dissertation work. Our studies demonstrate that following MHV-68 infection, unlike influenza infection, resulted in a …