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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
Bone Morphogenetic Proteins Shape TReg Cells, Piotr Kraj
Bone Morphogenetic Proteins Shape TReg Cells, Piotr Kraj
Biological Sciences Faculty Publications
The transforming growth factor-β (TGF-β) family includes cytokines controlling cell behavior, differentiation and homeostasis of various tissues including components of the immune system. Despite well recognized importance of TGF-β in controlling T cell functions, the immunomodulatory roles of many other members of the TGF-β cytokine family, especially bone morphogenetic proteins (BMPs), start to emerge. Bone Morphogenic Protein Receptor 1α (BMPR1α) is upregulated by activated effector and Foxp3+ regulatory CD4+ T cells (Treg cells) and modulates functions of both of these cell types. BMPR1α inhibits generation of proinflammatory Th17 cells and sustains peripheral Treg cells. This finding underscores the importance of …
Molecular Characterization And Related Aspects Of The Innate Immune Response In Ticks, Daniel E. Sonenshine, Wayne L. Hynes
Molecular Characterization And Related Aspects Of The Innate Immune Response In Ticks, Daniel E. Sonenshine, Wayne L. Hynes
Biological Sciences Faculty Publications
Compared to insects, little is known about innate immunity in ticks. This chapter addresses the molecular processes that recognize non-self and the cellular and molecular processes mobilized to phagocytose, engulf, inhibit or kill invaders. We discuss the receptors that recognize pathogen associated molecular patterns (PAMPs) and the putative up-regulation of regulatory cascades that lead, ultimately, to cellular or molecular responses. We describe the molecular events that activate the cellular processes and the array of humoral factors that are mobilized against invading organisms, including antimicrobial peptides, proteases and protease inhibitors, lectins, coagulation factors and others. Special attention is directed to the …