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Immunology and Infectious Disease Commons™
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Full-Text Articles in Immunology and Infectious Disease
The Effect Of Age On Neurological Inflammation To Acute Sleep Fragmentation In Mice, Molly Taylor
The Effect Of Age On Neurological Inflammation To Acute Sleep Fragmentation In Mice, Molly Taylor
Mahurin Honors College Capstone Experience/Thesis Projects
Obstructive sleep apnea is identified by recurring events of airway collapse during sleep, intermittent hypoxia, and perturbations in sleep continuity, known as sleep fragmentation. There is evidence to suggest that elderly patients are more at risk of developing obstructive sleep apnea. The purpose of this study was to assess whether age affects neurological inflammatory responses to acute sleep fragmentation. This assessment was made by subjecting young (4-5 months old) and old (10-11 months old) male C57BL/6j mice to automated sleep fragmentation, as well as having mice in both age categories as a control with no sleep fragmentation, for twenty-four hours. …
Effects Of Alpha- And Beta-Adrenergic Receptor Blockade Upon Inflammatory Responses To Acute And Chronic Sleep Fragmentation, Nicholas David Wheeler
Effects Of Alpha- And Beta-Adrenergic Receptor Blockade Upon Inflammatory Responses To Acute And Chronic Sleep Fragmentation, Nicholas David Wheeler
Masters Theses & Specialist Projects
Generally, sleep is viewed as a recuperative process and its dysregulation has
cognitive, metabolic, immunological, and inflammatory implications that are largely deleterious to human health. Epidemiological and empirical studies have suggested that sleep fragmentation (SF) as result of obstructive sleep apnea (OSA) and other sleep abnormalities leads to pronounced systemic inflammatory responses, which are influenced by the sympathetic nervous system (SNS). However, the underlying molecular mechanisms contributing to SNS regulation of SF-induced inflammatory states are not fully understood. To assess the effects of the SNS system, C57BL/6j female mice were placed in automated SF chambers (12L:12D) and subjected to either …
Immune Responses In Hibernating Little Brown Myotis (Myotis Lucifugus) With White-Nose Syndrome, Thomas M. Lilley, Jenni M. Prokkola, Elisabeth Jeanine Rogers, Sarah Gronsky, Allen Kurta, Deeann Reeder, Kenneth A. Field
Immune Responses In Hibernating Little Brown Myotis (Myotis Lucifugus) With White-Nose Syndrome, Thomas M. Lilley, Jenni M. Prokkola, Elisabeth Jeanine Rogers, Sarah Gronsky, Allen Kurta, Deeann Reeder, Kenneth A. Field
Faculty Journal Articles
White-nose syndrome (WNS) is a fungal disease responsible for decimating many bat populations in North America. Pseudogymnoascus destructans (Pd), the psychrophilic fungus responsible for WNS, prospers in the winter habitat of many hibernating bat species. The immune response that Pd elicits in bats is not yet fully understood; antibodies are produced in response to infection by Pd, but they may not be protective and indeed may be harmful. To understand how bats respond to infection during hibernation, we studied the effect of Pd inoculation on the survival and gene expression of captive hibernating Myotis lucifugus with varying …