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Full-Text Articles in Immunology and Infectious Disease
Crispr/Cas9-Induced Genetic Disruption And Characterization Of Udp-Galactopyranose Mutase In Trypanosoma Cruzi, Claudia Manriquez
Crispr/Cas9-Induced Genetic Disruption And Characterization Of Udp-Galactopyranose Mutase In Trypanosoma Cruzi, Claudia Manriquez
Open Access Theses & Dissertations
The protozoan parasite, Trypanosoma cruzi, is the causative agent of Chagas disease (ChD), or American trypanosomiasis, which affects 6-8 million people in Latin America. It is estimated that 2-3 million people will develop severe lifelong cardiac and/or digestive disorders. ChD has become a life threat not only to endemic regions but most recently also to nonendemic regions, including the United States, owing to extensive worldwide migration in recent years. The lack of a vaccine and the limited efficacy of the two drug treatments available make it urgent to develop novel therapies to treat such a threatening disease. UDP-Galactopyranose mutase (UGM) …