Genetics and Genomics Commons^™

Genetic And Functional Characterization Of Novel Host Factors Regulating Virus Infection In Caenorhabditis Elegans, Luis Enrique Sandoval

Arts & Sciences Electronic Theses and Dissertations

Viruses infect the majority of eukaryotic life on the planet and remain a global threat to human health. These pathogens are constrained to intracellular life cycles, as they exploit and rely on host factors and machinery throughout their entire reproduction process. While many of these viral life cycle factors have been reported and studied, our knowledge in the identity and function of these factors remains incomplete and a challenge in fundamental virology and the development of antiviral therapeutics. Caenorhabditis elegans offers an innovative approach for discovering novel host factors required for virus infection in a multicellular and simple model organism. …