Genetics and Genomics Commons^™

Catp-6, A C. Elegans Ortholog Of Atp13a2 Park9, Positively Regulates Gem-1, An Slc16a Transporter, Eric J. Lambie, Pamela J. Tieu, Nadja Lebedeva, Diane L. Church, Barbara Conradt

Dartmouth Scholarship

In previous work, we found that gain-of-function mutations that hyperactivate GEM-1 (an SLC16A transporter protein) can bypass the requirement for GON-2 (a TRPM channel protein) during the initiation of gonadogenesis in C. elegans . Consequently, we proposed that GEM-1 might function as part of a Mg 2 + uptake pathway that functions in parallel to GON- 2. In this study, we report that CATP-6, a C. elegans ortholog of the P5B ATPase, ATP13A2 (PARK9), is necessary for gem-1 gain-of-function mutations to suppress the effects of gon-2 inactivation. One possible explanation for this observation is that GEM-1 serves to activate CATP-6, …