Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Genetics and Genomics
Artificial Intelligence – Ii: Network Path Optimization Using Ga Approach, Madiha Sarfraz, Shaleeza Sohail, Younus Javed, Almas Anjum
Artificial Intelligence – Ii: Network Path Optimization Using Ga Approach, Madiha Sarfraz, Shaleeza Sohail, Younus Javed, Almas Anjum
International Conference on Information and Communication Technologies
In this paper, we present a variation of Genetic Algorithm (GA) for finding the Optimized shortest path of the network. The algorithm finds the optimal path based on the bandwidth and utilization of the network. The main distinguishing element of this work is the use of ldquo2-point over 1-point crossoverrdquo. The population comprises of all chromosomes (feasible and infeasible). Moreover, it is of variable length, so that the algorithm can perform efficiently in all scenarios. Rankbased selection is used for cross-over operation. Therefore, the best chromosomes crossover and give the most suitable offsprings. If the resulting offsprings are least fitted, …
The Role Of Rpoe In Stationary Phase Mutagenesis In Bacillus, Turquoise C. Alexander, Eduardo A. Robleto
The Role Of Rpoe In Stationary Phase Mutagenesis In Bacillus, Turquoise C. Alexander, Eduardo A. Robleto
Undergraduate Research Opportunities Program (UROP)
Stationary phase mutagenesis is a phenomenon whereby random mutations are generated in non-dividing cells. In order to understand how these mutations arise, we use Bacillus subtilis, a gram positive rod-shaped model organism. It is hypothesize that increased transcription promotes stationary phase mutagenesis in this organism. We therefore examined the role of rpoE, a gene that encodes RNA polymerase ! subunit and proposed to influence efficiency of transcription. To this end, we will first generate a strain bearing a deletion in the rpoE gene. In order to determine if this gene is important for mutagenesis, we will examine the accumulation of …
Dna Secondary Structures And Their Contribution To Mutagenesis In B. Subtilis Stationary Phase Cells, Carmen Vallin, Katherine Ona, Chris Ross, Ronald E. Yasbin, Eduardo A. Robleto
Dna Secondary Structures And Their Contribution To Mutagenesis In B. Subtilis Stationary Phase Cells, Carmen Vallin, Katherine Ona, Chris Ross, Ronald E. Yasbin, Eduardo A. Robleto
Undergraduate Research Opportunities Program (UROP)
It is widely known and accepted that the cause of many mutations in cells are generated during the replication process of actively dividing cells, however more recent research has shown that mutations also arise in non growing conditions, a phenomenon known stationary phase mutagenesis. Much of what is known come from studies in eukaryotic and bacterial models. It is proposed that in nongrowing cells, the process of transcription plays an important role in mutagenesis. I will test the hypothesis that secondary structures formed of DNA generated transcription promote mutagenesis. The sequences transcriptiongenerated structures are speculated to be prone to mutations …