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Articles 1 - 11 of 11
Full-Text Articles in Genetics and Genomics
Book Review Of "Of Flies, Mice, And Men: On The Revolution In Molecular Biology, By One Of The Scientists Who Helped Make It" By François Jacob, Nancy Curtis
Library Staff Publications
No abstract provided.
Drosophila Unpaired Encodes A Secreted Protein That Activates The Jak Signaling Pathway, Douglas A. Harrison, Patricia E. Mccoon, Richard Binari, Michael Gilman, Norbert Perrimon
Drosophila Unpaired Encodes A Secreted Protein That Activates The Jak Signaling Pathway, Douglas A. Harrison, Patricia E. Mccoon, Richard Binari, Michael Gilman, Norbert Perrimon
Biology Faculty Publications
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a …
Mutational Analysis Of A Transcriptional Activation Region Of The Vp16 Protein Of Herpes Simplex Virus, Susan M. Sullivan, Peter J. Horn, Victoria A. Olson, Allen H. Koop
Mutational Analysis Of A Transcriptional Activation Region Of The Vp16 Protein Of Herpes Simplex Virus, Susan M. Sullivan, Peter J. Horn, Victoria A. Olson, Allen H. Koop
University Faculty Publications and Creative Works
The VP16 protein of herpes simplex virus is a potent transcriptional activator of the viral immediate early genes. The transcriptional activation region of VP16 can be divided into two functional subregions, here designated VP16N (comprising amino acids 413-456) and VP16C (amino acids 450-490). Assays of VP16C mutants resulting from both random and alanine-scanning mutagenesis indicated that the sidechains of three phenylalanines (at positions 473, 475 and 479) and one acidic residue (glutamate 476) are important for transcriptional activation. Aromatic and bulky hydrophobic amino acids were effective substitutes for each of the three Phe residues, whereas replacement with smaller or polar …
Influence Of The Ccr2-V64i Polymorphism On Human Immunodeficiency Virus Type 1 Coreceptor Activity And On Chemokine Receptor Function Of Ccr2b, Ccr3, Ccr5, And Cxcr4, Benhur Lee, Benjamin J. Doranz, Shalini Rana, Yanji Yi, Mario Mellado, Jose M. R. Frade, Carlos Martinez-A., Stephen J. O'Brien, Michael Dean, Ronald G. Collman, Robert W. Doms
Influence Of The Ccr2-V64i Polymorphism On Human Immunodeficiency Virus Type 1 Coreceptor Activity And On Chemokine Receptor Function Of Ccr2b, Ccr3, Ccr5, And Cxcr4, Benhur Lee, Benjamin J. Doranz, Shalini Rana, Yanji Yi, Mario Mellado, Jose M. R. Frade, Carlos Martinez-A., Stephen J. O'Brien, Michael Dean, Ronald G. Collman, Robert W. Doms
Biology Faculty Articles
The chemokine receptors CCR5 and CXCR4 are used by human immunodeficiency virus type 1 (HIV-1) in conjunction with CD4 to infect cells. In addition, some virus strains can use alternative chemokine receptors, including CCR2b and CCR3, for infection. A polymorphism in CCR2 (CCR2-V64I) is associated with a 2- to 4-year delay in the progression to AIDS. To investigate the mechanism of this protective effect, we studied the expression of CCR2b and CCR2b-V64I, their chemokine and HIV-1 coreceptor activities, and their effects on the expression and receptor activities of the major HIV-1 coreceptors. CCR2b and CCR2b-V64I were expressed at …
Identification Of Putative Cytoskeletal Protein Homologues In The Protozoan Host Hartmannella Vermiformis As Substrates For Induced Tyrosine Phosphatase Activity Upon Attachment To The Legionnaires' Disease Bacterium, Legionella Pneumophila, Chandrasekar Venkataraman, Lian-Yang Gao, Subbarao Bondada, Yousef Abu Kwaik
Identification Of Putative Cytoskeletal Protein Homologues In The Protozoan Host Hartmannella Vermiformis As Substrates For Induced Tyrosine Phosphatase Activity Upon Attachment To The Legionnaires' Disease Bacterium, Legionella Pneumophila, Chandrasekar Venkataraman, Lian-Yang Gao, Subbarao Bondada, Yousef Abu Kwaik
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The Legionnaires' disease bacterium, Legionella pneumophila, is a facultative intracellular pathogen that invades and replicates within two evolutionarily distant hosts, free living protozoa and mammalian cells. Invasion and intracellular replication within protozoa are thought to be major factors in the transmission of Legionnaires' disease. We have recently reported the identification of a galactose/N-acetyl-d-galactosamine (Gal/GalNAc) lectin in the protozoan host Hartmannella vermiformis as a receptor for attachment and invasion by L. pneumophila (Venkataraman, C., B.J. Haack, S. Bondada, and Y.A. Kwaik. 1997. J. Exp. Med. 186:537–547). In this report, we extended our studies to the …
Heritability Of Expression Of The 70kd Heat-Shock Protein In Drosophila Melanogaster And Its Relevance To The Evolution Of Thermotolerance, Robert A. Krebs, Martin E. Feder, Jeehyun Lee
Heritability Of Expression Of The 70kd Heat-Shock Protein In Drosophila Melanogaster And Its Relevance To The Evolution Of Thermotolerance, Robert A. Krebs, Martin E. Feder, Jeehyun Lee
Biological, Geological, and Environmental Faculty Publications
The principle inducible heat-shock protein of Drosophila melanogasrer, Hsp70, contributes to thermotolerance throughout the entire life cycle of the species but may also reduce fitness in some life stages. In principle, selection might maximize the benefits of Hsp70 expression relative to its costs by adjusting the magnitude of Hsp70 expression for each life-cycle stage independently. Therefore we examined whether the magnitude of Hsp70 ex pre sion varied during the life cycle and the relationship of this variation to several life-history traits. For 28 isofemale lines derived from a single natural population, estimates of heritable variation in Hsp70 expression ranged between …
An Investigation Of Crystalline Intensity Of The Wood Of Poplar Clones Grown In Jiangsu Province, China, Bernard R. Parresol, Fuliang Cao
An Investigation Of Crystalline Intensity Of The Wood Of Poplar Clones Grown In Jiangsu Province, China, Bernard R. Parresol, Fuliang Cao
Aspen Bibliography
No abstract provided.
Consequences Of Differing Wool Growth Rates On Staple Strength Of Merino Wethers With Divergent Staple Strengths, A. C. Schlink, G. Mata, R. M. Lewis
Consequences Of Differing Wool Growth Rates On Staple Strength Of Merino Wethers With Divergent Staple Strengths, A. C. Schlink, G. Mata, R. M. Lewis
Department of Animal Science: Faculty Publications
An experiment was conducted to determine the effects of dietary protein intake after a period of weight loss on the wool components of staple strength for sheep with a history of low or high staple strength (18.0 vs 34 Nlktex). After being fed to lose 15% of their liveweight over 10 weeks, sheep within each staple strength group were assigned in equal numbers to either a low or high protein diet designed to re-gain initialliveweight in 8 weeks. Liveweight, feed intakes and the growth, fibre diameter and fibre length characteristics of wool were measured at regular intervals. After the weight …
Title, Fergus Ryan, D Devaney, Caroline Joyce, A Nestorowicz, M Permutt, Benjamin Glaser, Paul Thornton, David E. Barton
Title, Fergus Ryan, D Devaney, Caroline Joyce, A Nestorowicz, M Permutt, Benjamin Glaser, Paul Thornton, David E. Barton
Articles
Persistent hypoglycaemia in infancy is most commonly caused by hyperinsulinism. A case is reported of the somatic loss of the maternal 11p in an insulin secreting focal adenoma in association with a germline SUR-1mutation on the paternal allele in a baby boy with hyperinsulinism diagnosed at 49 days old. A reduction to homozygosity of an SUR-1 mutation is proposed as a critical part of the cause of focal hyperinsulinism.
Multiple Members Of A Third Subfamily Of P-Type Atpases Identified By Genomic Sequences And Ests, Margaret S. Halleck, Deepti Pradhan, Christie Blackman, Charlotte A. Berkes, Partrick Williamson, Robert A. Schlegel
Multiple Members Of A Third Subfamily Of P-Type Atpases Identified By Genomic Sequences And Ests, Margaret S. Halleck, Deepti Pradhan, Christie Blackman, Charlotte A. Berkes, Partrick Williamson, Robert A. Schlegel
Biology Faculty Publications
The Saccharomyces cerevisiae genome contains five P-type ATPases divergent from both of the well-known subfamilies of these membrane ion transporters. This newly recognized third subfamily can be further divided into four classes of genes with nearly equal relatedness to each other. Genes of this new subfamily are also present and expressed in multicellular organisms such as Caenorhabditis elegans and mammals; some, but not all, can be assigned to the classes identified in yeast. Different classes of genes and different genes within a class are expressed differentially in tissues of the mouse. The recently cloned gene for the mammalian aminophospholipid translocase …
Toward A Framework Of Mutualism: The Jewish Community In Genetics Research, Karen H. Rothenberg, Amy B. Rutkin
Toward A Framework Of Mutualism: The Jewish Community In Genetics Research, Karen H. Rothenberg, Amy B. Rutkin
Faculty Scholarship
No abstract provided.