Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Keyword
-
- Amino Acid Sequence (1)
- Animals (1)
- Base Pairing (1)
- Base Sequence (1)
- Cytokines (1)
-
- DNA-Binding Proteins (1)
- Developmental (1)
- Drosophila (1)
- Drosophila Proteins (1)
- Embryo, Nonmammalian (1)
- Extracellular Matrix Proteins (1)
- Gene Expression Regulation (1)
- Gene Expression Regulation, Developmental (1)
- Genes, Insect (1)
- Genetic Transcription (1)
- Glycoproteins (1)
- Insect (1)
- Insect Proteins (1)
- Janus Kinases (1)
- Molecular Sequence Data (1)
- Nonmammalian Embryo (1)
- Protein-Tyrosine Kinases (1)
- Receptor Protein-Tyrosine Kinases (1)
- STAT Transcription Factors (1)
- Signal Transduction (1)
- Trans-Activators (1)
- Transcription Factors (1)
- Transcription, Genetic (1)
Articles 1 - 2 of 2
Full-Text Articles in Genetics and Genomics
Drosophila Unpaired Encodes A Secreted Protein That Activates The Jak Signaling Pathway, Douglas A. Harrison, Patricia E. Mccoon, Richard Binari, Michael Gilman, Norbert Perrimon
Drosophila Unpaired Encodes A Secreted Protein That Activates The Jak Signaling Pathway, Douglas A. Harrison, Patricia E. Mccoon, Richard Binari, Michael Gilman, Norbert Perrimon
Biology Faculty Publications
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a …
Multiple Members Of A Third Subfamily Of P-Type Atpases Identified By Genomic Sequences And Ests, Margaret S. Halleck, Deepti Pradhan, Christie Blackman, Charlotte A. Berkes, Partrick Williamson, Robert A. Schlegel
Multiple Members Of A Third Subfamily Of P-Type Atpases Identified By Genomic Sequences And Ests, Margaret S. Halleck, Deepti Pradhan, Christie Blackman, Charlotte A. Berkes, Partrick Williamson, Robert A. Schlegel
Biology Faculty Publications
The Saccharomyces cerevisiae genome contains five P-type ATPases divergent from both of the well-known subfamilies of these membrane ion transporters. This newly recognized third subfamily can be further divided into four classes of genes with nearly equal relatedness to each other. Genes of this new subfamily are also present and expressed in multicellular organisms such as Caenorhabditis elegans and mammals; some, but not all, can be assigned to the classes identified in yeast. Different classes of genes and different genes within a class are expressed differentially in tissues of the mouse. The recently cloned gene for the mammalian aminophospholipid translocase …