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Full-Text Articles in Genetics and Genomics
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Physiology Faculty Publications
Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer’s disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both insulin resistance (IR) and E4 are associated with metabolic and vascular impairments. Deficits in cerebral metabolism and cerebrovascular function have been proposed as initiating events leading to these impairments. …
Apolipoprotein E4 And Insulin Resistance Interact To Impair Cognition And Alter The Epigenome And Metabolome, Lance A. Johnson, Eileen Ruth S. Torres, Soren Impey, Jan F. Stevens, Jacob Raber
Apolipoprotein E4 And Insulin Resistance Interact To Impair Cognition And Alter The Epigenome And Metabolome, Lance A. Johnson, Eileen Ruth S. Torres, Soren Impey, Jan F. Stevens, Jacob Raber
Physiology Faculty Publications
Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer’s disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could explain their overlapping pathophysiology have yet to be found. We hypothesized that, compared to E3 mice, E4 mice would be more susceptible to the harmful cognitive effects of high fat diet (HFD)-induced IR due to apoE isoform-specific differences in brain metabolism. While both E3 and E4 mice fed HFD displayed impairments in peripheral metabolism and cognition, deficits in …