Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Genetics and Genomics
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Evolution Of Duplicated Β-Globin Genes And The Structural Basis Of Hemoglobin Isoform Differentiation In Mus, Amy M. Runck, Hideaki Moriyama, Jay F. Storz
Jay F. Storz Publications
The functional diversification of multigene families may be strongly influenced by mechanisms of concerted evolution such as interparalog gene conversion. The β-globin gene family of house mice (genus Mus) represents an especially promising system for evaluating the effects of gene conversion on the functional divergence of duplicated genes. Whereas the majority of mammalian species possess tandemly duplicated copies of the adult β-globin gene that are identical in sequence, natural populations of house mice are often polymorphic for distinct two-locus haplotypes that differ in levels of functional divergence between duplicated β-globin genes, HBB-T1 and HBB-T2. Here, we use a phylogenetic …
Rapid Rates Of Lineage-Specific Gene Duplication And Deletion In The Α-Globin Gene Family, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz
Rapid Rates Of Lineage-Specific Gene Duplication And Deletion In The Α-Globin Gene Family, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz
Jay F. Storz Publications
Phylogeny reconstructions of the globin gene families have revealed that paralogous genes within species are often more similar to one another than they are to their orthologous counterparts in closely related species. This pattern has been previously attributed to mechanisms of concerted evolution such as interparalog gene conversion that homogenize sequence variation between tandemly duplicated genes and therefore create the appearance of recent common ancestry. Here we report a comparative genomic analysis of the α-globin gene family in mammals that reveal a surprisingly high rate of lineage-specific gene duplication and deletion via unequal crossing-over. Results of our analysis reveal that …