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Full-Text Articles in Genetics and Genomics
Oxygenation Properties And Oxidation Rates Of Mouse Hemoglobins That Differ In Reactive Cysteine Content, Jay F. Storz, Roy E. Weber, Angela Fago
Oxygenation Properties And Oxidation Rates Of Mouse Hemoglobins That Differ In Reactive Cysteine Content, Jay F. Storz, Roy E. Weber, Angela Fago
Jay F. Storz Publications
House mice (genus Mus) harbor extensive allelic variation at two tandemly duplicated genes that encode the β-chain subunits of adult hemoglobin (Hb). Alternative haplotypes differ in the level of sequence divergence between the two β-globin gene duplicates: the Hbbd and Hbbp haplotypes harbor two structurally distinct β-globin genes, whereas the Hbbs haplotype harbors two β-globin duplicates that are identical in sequence. One especially salient difference between the s-type Hbs relative to the d- and p-type Hbs relates to the number of reactive β-chain cysteine residues. In addition to the highly conserved cysteine residue …
Regulatory Changes Contribute To The Adaptive Enhancement Of Thermogenic Capacity In High-Altitude Deer Mice, Zachary A. Cheviron, Gwendolyn C. Bachman, Alex D. Connaty, Jay F. Storz
Regulatory Changes Contribute To The Adaptive Enhancement Of Thermogenic Capacity In High-Altitude Deer Mice, Zachary A. Cheviron, Gwendolyn C. Bachman, Alex D. Connaty, Jay F. Storz
Jay F. Storz Publications
In response to hypoxic stress, many animals compensate for a reduced cellular O2 supply by suppressing total metabolism, thereby reducing O2 demand. For small endotherms that are native to high-altitude environments, this is not always a viable strategy, as the capacity for sustained aerobic thermogenesis is critical for survival during periods of prolonged cold stress. For example, survivorship studies of deer mice (Peromyscus maniculatus) have demonstrated that thermogenic capacity is under strong directional selection at high altitude. Here, we integrate measures of whole-organism thermogenic performance with measures of metabolic enzyme activities and genomic transcriptional profiles to …