Genetics and Genomics Commons^™

Phylogenetic Portrait Of The Saccharomyces Cerevisiae Functional Genome, Patrick A. Gibney, Mark J. Hickman, Patrick H. Bradley, John C. Matese, David Botstein

Faculty Scholarship for the College of Science & Mathematics

The genome of budding yeast (Saccharomyces cerevisiae) contains approximately 5800 protein-encoding genes, the majority of which are associated with some known biological function. Yet the extent of amino acid sequence conservation of these genes over all phyla has only been partially examined. Here we provide a more comprehensive overview and visualization of the conservation of yeast genes and a means for browsing and exploring the data in detail, down to the individual yeast gene, at http://yeast-phylogroups.princeton.edu. We used data from the OrthoMCL database, which has defined orthologs from approximately 150 completely sequenced genomes, including diverse representatives of …