Genetics and Genomics Commons^™

Development And Integration Of Informatic Tools For Qualitative And Quantitative Characterization Of Proteomic Datasets Generated By Tandem Mass Spectrometry, Rachel Michelle Adams

Doctoral Dissertations

Shotgun proteomic experiments provide qualitative and quantitative analytical information from biological samples ranging in complexity from simple bacterial isolates to higher eukaryotes such as plants and humans and even to communities of microbial organisms. Improvements to instrument performance, sample preparation, and informatic tools are increasing the scope and volume of data that can be analyzed by mass spectrometry (MS). To accommodate for these advances, it is becoming increasingly essential to choose and/or create tools that can not only scale well but also those that make more informed decisions using additional features within the data. Incorporating novel and existing tools into …