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Full-Text Articles in Genetics and Genomics
The Gli-Kruppel Family Of Human Genes, John M. Ruppert, Kenneth W. Kinzler, Albert J. Wong, Sandra H. Bigner, Fa-Ten Kao, Martha L. Law, Hector Seuanez, Stephen J. O'Brien, Bert Vogelstein
The Gli-Kruppel Family Of Human Genes, John M. Ruppert, Kenneth W. Kinzler, Albert J. Wong, Sandra H. Bigner, Fa-Ten Kao, Martha L. Law, Hector Seuanez, Stephen J. O'Brien, Bert Vogelstein
Biology Faculty Articles
Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), a Drosophila segmentation gene of the gap class. We have used the GLI cDNA as a molecular probe to isolate related sequences from the human genome. Partial characterization of six related loci, including sequence determination, expression studies, and chromosome localization, revealed that each locus could encode a separate finger protein. The predicted proteins all had similar H-C links, i.e., a conserved stretch of 9 …
The Κ-Deleting Element: Germline And Rearranged, Duplicated And Dispersed Forms, Winfried B. Graninger, Paula L. Goldman, Cynthia C. Morton, Stephen J. O'Brien, Stanley J. Korsmeyer
The Κ-Deleting Element: Germline And Rearranged, Duplicated And Dispersed Forms, Winfried B. Graninger, Paula L. Goldman, Cynthia C. Morton, Stephen J. O'Brien, Stanley J. Korsmeyer
Biology Faculty Articles
Human light chain genes are used in a κ before λ order. Accompanying this hierarchy is the rearrangement of a κ-deleting element (Kde) which eliminates the kappa locus before λ gene rearrangement. In approximately 60% of rearrangements the Kde recombines at a conserved heptamer within the Jκ-Cκ intron. We demonstrated that aberrant V/J rearrangements possessing apparent "N" nucleotides existed 5' to the Jκ-Kde rearrangements. This suggests that the Kde may selectively eliminate nonfunctional V/J alleles. A κ-producing cell that displayed the unusual finding of λ gene rearrangement demonstrated a rearranged Kde. This rearrangement was a …
Mammalian Genome Organization: An Evolutionary View, S. J. O'Brien, H. N.J.E. Seuanez Womack
Mammalian Genome Organization: An Evolutionary View, S. J. O'Brien, H. N.J.E. Seuanez Womack
Biology Faculty Articles
No abstract provided.