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Articles 1 - 4 of 4
Full-Text Articles in Genetics and Genomics
Population Genomics And Phylogeography Of A Benthic Coastal Shark (Scyliorhinus Canicula) Using 2b-Rad Single Nucleotide Polymorphisms, Alice Manuzzi, Lorenzo Zane, Antonio Munoz-Merida, Andrew M. Griffiths, Ana Verissimo
Population Genomics And Phylogeography Of A Benthic Coastal Shark (Scyliorhinus Canicula) Using 2b-Rad Single Nucleotide Polymorphisms, Alice Manuzzi, Lorenzo Zane, Antonio Munoz-Merida, Andrew M. Griffiths, Ana Verissimo
VIMS Articles
The existence of strong genetic structure is expected in species with limited ability to disperse and philopatric behaviour. These life-history traits are found in many small benthic elasmobranchs, such as in the small-spotted catshark (Scyliorhinus canicula). However, no evidence of genetic structure was found across its northeastern Atlantic (NEA) range using traditional molecular markers. Here, fine-scale genetic differentiation was detected between the British Isles and southern Iberia using 2674 single nucleotide polymorphism loci generated using 2b-restriction site-associated DNA (2b-RAD). Geographical distance and historical demography were two major drivers shaping the distribution of genetic diversity of S. canicula along …
Sumo-Targeted Ubiquitin Ligases (Stubls) Reduce The Toxicity And Abnormal Transcriptional Activity Associated With A Mutant, Aggregation-Prone Fragment Of Huntingtin, Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Oliver Kerscher
Sumo-Targeted Ubiquitin Ligases (Stubls) Reduce The Toxicity And Abnormal Transcriptional Activity Associated With A Mutant, Aggregation-Prone Fragment Of Huntingtin, Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Oliver Kerscher
Arts & Sciences Articles
Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington’s Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associated with a mutant, aggregation-prone fragment of huntingtin (Htt), the causative agent of HD. We demonstrate that expression of an aggregation-prone Htt construct with 103 glutamine residues (103Q), but not the non-expanded form (25Q), results in severe growth defects in slx5Δ and slx8Δ cells. Since Slx5 is a nuclear protein and because Htt expression affects gene transcription, we …
Genetic Analyses Of Striped Bass In The Chesapeake Bay: An Investigation Of Connectivity Among Virginia Subestuaries And An Evaluation Of Close-Kinship Mark Recapture Methodology To Estimate Spawning Abundance., Savannah Michaelsen
Dissertations, Theses, and Masters Projects
The striped bass (Morone saxatilis) is an anadromous fish distributed along the eastern coast of North America that currently supports one of the most lucrative and important commercial and recreational fisheries in the region. Since the recovery of the Atlantic stock after a collapse in the late 1970s, studies have focused on understanding the connectivity of major spawning grounds and improving methods of abundance estimation. Studies support strong site fidelity of striped bass to major estuaries along the Atlantic coast, but there has been disagreement about connectivity within the largest spawning ground, the Chesapeake Bay. Additionally, no estimates exist for …
Multi-Scale Phylogenomics Of Gadiformes With Emphasis On Hakes (Merluccius, Merlucciidae), Adela Y. Roa-Varon
Multi-Scale Phylogenomics Of Gadiformes With Emphasis On Hakes (Merluccius, Merlucciidae), Adela Y. Roa-Varon
Dissertations, Theses, and Masters Projects
Gadiformes include some of the most important commercially harvested fishes in the world (e.g. cods, hakes, and grenadiers). Currently, different authors recognize anywhere between 11 and 14 families, approximately 84 genera, and over 600 species. The monophyly of the order has been supported by both morphological and molecular data, yet the relationships among families and subfamilies remain poorly understood and interpreting phylogenetic patterns to date has been difficult. My dissertation research on multi-scale phylogenetics of Gadiformes with emphasis on hakes (Merluccius, Merlucciidae) has three primary objectives: (1) to improve the understanding of the phylogenetic relationships among families of Gadiformes (Teleostei); …