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Articles 1 - 3 of 3
Full-Text Articles in Genetics and Genomics
Sitehound-Web: A Server For Ligand Binding Site Identification In Protein Structures, Marylens Hernandez, Dario Ghersi, Roberto Sanchez
Sitehound-Web: A Server For Ligand Binding Site Identification In Protein Structures, Marylens Hernandez, Dario Ghersi, Roberto Sanchez
Interdisciplinary Informatics Faculty Publications
SITEHOUND-web (http://sitehound.sanchezlab.org) is a binding-site identification server powered by the SITEHOUND program. Given a protein structure in PDB format SITEHOUND-web will identify regions of the protein characterized by favorable interactions with a probe molecule. These regions correspond to putative ligand binding sites. Depending on the probe used in the calculation, sites with preference for different ligands will be identified. Currently, a carbon probe for identification of binding sites for drug-like molecules, and a phosphate probe for phosphorylated ligands (ATP, phoshopeptides, etc.) have been implemented. SITEHOUND-web will display the results in HTML pages including an interactive 3D representation of …
A Genome Scan For Quantitative Trait Loci Affecting Male Reproductive Traits In A White Duroc × Chinese Erhualian Resource Population, Dongren Ren, J. Ren, Y. Y. Xing, Y. M. Guo, Y. B. Wu, G. C. Yang, H. R. Mao
A Genome Scan For Quantitative Trait Loci Affecting Male Reproductive Traits In A White Duroc × Chinese Erhualian Resource Population, Dongren Ren, J. Ren, Y. Y. Xing, Y. M. Guo, Y. B. Wu, G. C. Yang, H. R. Mao
Psychology Faculty Publications
Chinese Erhualian boars have dramatically smaller testes, greater concentrations of circulating androgens, and fewer Sertoli cells than Western commercial breeds. To identify QTL for boar reproductive traits, testicular weight, epididymal weight, seminiferous tubular diameter at 90 and 300 d, and serum testosterone concentration at 300 d were measured in 347 F2 boars from a White Duroc × Chinese Erhualian cross. A whole genome scan was performed with 183 microsatellites covering 19 porcine chromosomes. A total of 16 QTL were identified on 9 chromosomes, including 1% genome-wide significant QTL for testicular weight at 90 and 300 d and seminiferous tubular …
Estrogenic Compounds Downstream From Three Small Cities In Eastern Nebraska: Occurrence And Biological Effect, Marlo K. Sellin, Daniel D. Snow, Debbie L. Akerly, Alan S. Kolok
Estrogenic Compounds Downstream From Three Small Cities In Eastern Nebraska: Occurrence And Biological Effect, Marlo K. Sellin, Daniel D. Snow, Debbie L. Akerly, Alan S. Kolok
Biology Faculty Publications
Recent studies have detected estrogenic compounds in surface waters in North America and Europe. Furthermore, the presence of estrogenic compounds in surface waters has been attributed, in some cases, to the discharge of wastewater treatment plant (WWTP) effluent. The primary objective of the current study was to determine if WWTP effluent contributes estrogens to the surface waters of Nebraska. A second objective of this study was to determine if estrogens were found in concentrations sufficient enough to manifest feminizing effects on fish. These objectives were satisfied by deploying polar organic chemical integrative samplers (POCIS) and caged fathead minnows at eight …