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Oxygenation Properties And Oxidation Rates Of Mouse Hemoglobins That Differ In Reactive Cysteine Content, Jay F. Storz, Roy E. Weber, Angela Fago

Jay F. Storz Publications

House mice (genus Mus) harbor extensive allelic variation at two tandemly duplicated genes that encode the β-chain subunits of adult hemoglobin (Hb). Alternative haplotypes differ in the level of sequence divergence between the two β-globin gene duplicates: the Hbb^d and Hbb^p haplotypes harbor two structurally distinct β-globin genes, whereas the Hbb^s haplotype harbors two β-globin duplicates that are identical in sequence. One especially salient difference between the s-type Hbs relative to the d- and p-type Hbs relates to the number of reactive β-chain cysteine residues. In addition to the highly conserved cysteine residue …