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Full-Text Articles in Genetics and Genomics
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Apolipoprotein E4 Mediates Insulin Resistance-Associated Cerebrovascular Dysfunction And The Post-Prandial Response, Lance A. Johnson, Eileen Ruth Torres, Sydney Weber Boutros, Esha Patel, Tunde Akinyeke, Nabil J. Alkayed, Jacob Raber
Physiology Faculty Publications
Metabolic dysfunction, commonly a result of diets high in saturated fats and sugar, is associated with impaired cognitive function and an increased risk of age-related cognitive decline (ACD) and Alzheimer’s disease (AD). Compared to the E3 isoform of apolipoprotein (apoE), the E4 isoform is a major genetic risk factor for ACD, AD, and for developing cognitive impairments following various environmental challenges, including dietary challenges such as a high-fat diet (HFD). Both insulin resistance (IR) and E4 are associated with metabolic and vascular impairments. Deficits in cerebral metabolism and cerebrovascular function have been proposed as initiating events leading to these impairments. …