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Full-Text Articles in Genetics and Genomics
Comparative Analysis Of Linker Histone H1, Mecp2, And Hmgd1 On Nucleosome Stability And Target Site Accessibility, Caitlyn Riedmann, Yvonne N. Fondufe-Mittendorf
Comparative Analysis Of Linker Histone H1, Mecp2, And Hmgd1 On Nucleosome Stability And Target Site Accessibility, Caitlyn Riedmann, Yvonne N. Fondufe-Mittendorf
Molecular and Cellular Biochemistry Faculty Publications
Chromatin architectural proteins (CAPs) bind the entry/exit DNA of nucleosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outcomes. How CAPs mediate nucleosome dynamics is not well understood. We hypothesize that CAPs regulate DNA target site accessibility through alteration of the rate of spontaneous dissociation of DNA from nucleosomes. We investigated the effects of histone H1, high mobility group D1 (HMGD1), and methyl CpG binding protein 2 (MeCP2), on the biophysical properties of nucleosomes and chromatin. We show that MeCP2, like the repressive histone H1, traps the nucleosome in a more compact mononucleosome structure. Furthermore, histone …
Ten Simple Rules For Taking Advantage Of Git And Github, Yasset Perez-Riverol, Laurent Gatto, Rui Wang, Timo Sachsenberg, Julian Uszkoreit, Felipe Da Veiga Leprevost, Christian Fufezan, Tobias Ternent, Stephen J. Eglen, Daniel S. Katz, Tom J. Pollard, Alexander Konovalov, Robert M. Flight, Kai Blin, Juan Antonio Vizcaíno
Ten Simple Rules For Taking Advantage Of Git And Github, Yasset Perez-Riverol, Laurent Gatto, Rui Wang, Timo Sachsenberg, Julian Uszkoreit, Felipe Da Veiga Leprevost, Christian Fufezan, Tobias Ternent, Stephen J. Eglen, Daniel S. Katz, Tom J. Pollard, Alexander Konovalov, Robert M. Flight, Kai Blin, Juan Antonio Vizcaíno
Molecular and Cellular Biochemistry Faculty Publications
No abstract provided.
Transcriptional Profile Of Immediate Response To Ionizing Radiation Exposure, Eric C. Rouchka, Robert M. Flight, Brigitte H. Fasciotto, Rosendo Estrada, John W. Eaton, Phani K. Patibandla, Sabine J. Waigel, Dazhuo Li, John K. Kirtley, Palaniappan Sethu, Robert S. Keynton
Transcriptional Profile Of Immediate Response To Ionizing Radiation Exposure, Eric C. Rouchka, Robert M. Flight, Brigitte H. Fasciotto, Rosendo Estrada, John W. Eaton, Phani K. Patibandla, Sabine J. Waigel, Dazhuo Li, John K. Kirtley, Palaniappan Sethu, Robert S. Keynton
Molecular and Cellular Biochemistry Faculty Publications
Astronauts participating in long duration space missions are likely to be exposed to ionizing radiation associated with highly energetic and charged heavy particles. Previously proposed gene biomarkers for radiation exposure include phosphorylated H2A Histone Family, Member X (γH2AX), Tumor Protein 53 (TP53), and Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A). However, transcripts of these genes may not be the most suitable biomarkers for radiation exposure due to a lack of sensitivity or specificity. As part of a larger effort to develop lab-on-a-chip methods for detecting radiation exposure events using blood samples, we designed a dose–course microarray study in order to determine coding …