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Full-Text Articles in Genetics and Genomics
Evaluation Of An Adaptive Sampling Approach To Characterize Microbes Associated With Pneumonia In White-Tailed Deer, Claire Nowak
Evaluation Of An Adaptive Sampling Approach To Characterize Microbes Associated With Pneumonia In White-Tailed Deer, Claire Nowak
Honors College
Infectious diseases have a tremendous global impact, adversely affecting the health and well-being of humans, domestic livestock, and wildlife. Consequently, pathogen surveillance in wild animals is essential for managing the risk of disease transmission to humans and domesticated animals, as well as for understanding host-pathogen interactions. However, pathogen detection methods are often focused on one to a few pathogen species, which limits our understanding of the distributions and effects of multiple co-infecting pathogens on host individuals and populations. In this study, I employed a metagenomic sequencing approach to (1) characterize the microbial community in a white-tailed deer (Odocoileus virginianus …
Comprehensive Overview Of Causative Agents Of Alzheimer's Disease: Tau Protein And Amyloid Betas With Their Biochemical Pathways And Proposed Treatments Including Cost Analysis, Ethan Johnson
Honors College
Alzheimer’s is a neurodegenerative disease found within the brain, interfering with neuron function, eventually leading to widespread atrophy. The disease effects millions of Americans with neurofibrillary tangles and amyloid beta plaques, both protein deposits with unclear causes. The goal for this thesis was not only to understand how these proteins form but how to safely interfere with their production. This was completed by a comprehensive overview of the form of the buildups and their precursors, tau proteins and amyloid beta precursor protein, respectively. An emphasis was put on the molecular biology and genetic causes of the amyloids rather than the …