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Full-Text Articles in Genetics and Genomics
Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth
Cancer Cell Redirection Biomarker Discovery Using A Mutual Information Approach, Kimberly Roche, F. Alex Feltus, Jang Pyo Park, Marie-May Coissieux, Chenyan Chang, Vera B.S. Chan, Mohamed Bentires-Alj, Brian W. Booth
Publications
Introducing tumor-derived cells into normal mammary stem cell niches at a sufficiently high ratio of normal to tumorous cells causes those tumor cells to undergo a change to normal mammary phenotype and yield normal mammary progeny. This phenomenon has been termed cancer cell redirection. We have developed an in vitro model that mimics in vivo redirection of cancer cells by the normal mammary microenvironment. Using the RNA profiling data from this cellular model, we examined high-level characteristics of the normal, redirected, and tumor transcriptomes and found the global expression profiles clearly distinguish the three expression states. To identify potential redirection …
A Leishmania Secretion System For The Expression Of Major Ampullate Spidroin Mimics, Todd A. Lyda, Elizabeth L. Wagner, Andre X. Bourg, Congyue Peng, Golnaz Najaf Tomaraei, Delphine Dean, Marian S. Kennedy, William R. Marcotte Jr.
A Leishmania Secretion System For The Expression Of Major Ampullate Spidroin Mimics, Todd A. Lyda, Elizabeth L. Wagner, Andre X. Bourg, Congyue Peng, Golnaz Najaf Tomaraei, Delphine Dean, Marian S. Kennedy, William R. Marcotte Jr.
Publications
Spider major ampullate silk fibers have been shown to display a unique combination of relatively high fracture strength and toughness compared to other fibers and show potential for tissue engineering scaffolds. While it is not possible to mass produce native spider silks, the potential ability to produce fibers from recombinant spider silk fibers could allow for an increased innovation rate within tissue engineering and regenerative medicine. In this pilot study, we improved upon a prior fabrication route by both changing the expression host and additives to the fiber pulling precursor solution to improve the performance of fibers. The new expression …
Beyond The Mhc: A Canine Model Of Dermatomyositis Shows A Complex Pattern Of Genetic Risk Involving Novel Loci, Jacquelyn M. Evans, Rooksana E. Noorai, Kate L. Tsai, Alison N. Starr-Moss, Cody M. Hill, Kendall J. Anderson, Thomas R. Famula, Leigh Anne Clark
Beyond The Mhc: A Canine Model Of Dermatomyositis Shows A Complex Pattern Of Genetic Risk Involving Novel Loci, Jacquelyn M. Evans, Rooksana E. Noorai, Kate L. Tsai, Alison N. Starr-Moss, Cody M. Hill, Kendall J. Anderson, Thomas R. Famula, Leigh Anne Clark
Publications
Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression. We conducted genome-wide association studies in two modern breeds having common …