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Full-Text Articles in Genetics and Genomics
Regulation Of A Messenger: Raising Oskar, It Takes A Village, Livia V. Bayer
Regulation Of A Messenger: Raising Oskar, It Takes A Village, Livia V. Bayer
Dissertations, Theses, and Capstone Projects
D. melanogaster oogenesis serves as an excellent system to study the life of an mRNA. Tremendous work has been done to understand the numerous complex mechanisms of mRNA regulation, still there is still so much that is yet to be discovered. In this thesis, I present studies I carried out to address several aspects of oskar mRNA post-transcriptional regulation. Leading me to extend our current understanding of the carefully controlled regulation of oskar mRNA life cycle via a myriad of proteins. I found that a specific NPC component, Nup154 is necessary not only for its export from the nucleus, but …
Post-Transcriptional Regulation Of The Drosophila Anterior Determinant, Bicoid, John Mclaughlin
Post-Transcriptional Regulation Of The Drosophila Anterior Determinant, Bicoid, John Mclaughlin
Dissertations, Theses, and Capstone Projects
In a wide variety of biological contexts, messenger RNA (mRNA) is known to have a complex and dynamic life cycle. In particular, the localization and translational control of mRNA are essential for proper development in eukaryotes. The fly Drosophila melanogaster is an excellent model for studying these processes. During D. melanogaster oogenesis, several mRNAs are trafficked and localized within the developing egg chamber, and regulated at the translational level to enable embryo patterning. One such mRNA, bicoid, is localized at the anterior of the oocyte and translated in the early embryo, where its encoded protein directs formation of the fly's …