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Full-Text Articles in Genetics and Genomics
Post-Transcriptional Regulation Of The Drosophila Anterior Determinant, Bicoid, John Mclaughlin
Post-Transcriptional Regulation Of The Drosophila Anterior Determinant, Bicoid, John Mclaughlin
Dissertations, Theses, and Capstone Projects
In a wide variety of biological contexts, messenger RNA (mRNA) is known to have a complex and dynamic life cycle. In particular, the localization and translational control of mRNA are essential for proper development in eukaryotes. The fly Drosophila melanogaster is an excellent model for studying these processes. During D. melanogaster oogenesis, several mRNAs are trafficked and localized within the developing egg chamber, and regulated at the translational level to enable embryo patterning. One such mRNA, bicoid, is localized at the anterior of the oocyte and translated in the early embryo, where its encoded protein directs formation of the fly's …