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Full-Text Articles in Genetics and Genomics
An Investigation Of Information Structures In Dna, Joel Mohrmann
An Investigation Of Information Structures In Dna, Joel Mohrmann
Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research
The information-containing nature of the DNA molecule has been long known and observed. One technique for quantifying the relationships existing within the information contained in DNA sequences is an entity from information theory known as the average mutual information (AMI) profile. This investigation sought to use principally the AMI profile along with a few other metrics to explore the structure of the information contained in DNA sequences.
Treating DNA sequences as an information source, several computational methods were employed to model their information structure. Maximum likelihood and maximum a posteriori estimators were used to predict missing bases in DNA sequences. …