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Molecular Genetics

Selected Works

2012

Articles 1 - 13 of 13

Full-Text Articles in Genetics and Genomics

Evolution Of Repetitive Proteins: Spider Silks From Nephila Clavipes (Tetragnathidae) And Araneus Bicentenarius (Araneidae), Richard D. Beckwitt, Steven Arcidiacono, Robert Stote Dec 2012

Evolution Of Repetitive Proteins: Spider Silks From Nephila Clavipes (Tetragnathidae) And Araneus Bicentenarius (Araneidae), Richard D. Beckwitt, Steven Arcidiacono, Robert Stote

Richard D Beckwitt

Spider silks are highly repetitive proteins, characterized by regions of polyalanine and glycine-rich repeating units. We have obtained two variants of the Spidroin 1 (NCF-1) silk gene sequence from Nephila clavipes. One sequence (1726 bp) was from a cloned cDNA, and the other (1951 bp) was from PCR of genomic DNA. When these sequences are compared with each other and the previously published Spidroin 1 sequence, there are differences due to sequence rearrangements, as well as single base substitutions. These variations are similar to those that have been reported from other highly repetitive genes, and probably represent the results …

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Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu Oct 2012

Inhibition Of Herpes Simplex Virus Type 1 With The Modified Green Tea Polyphenol Pamitoyl-Epigallocatechin Gallate., Aline De Oliveira, Sandra Adams, Lee Lee, Sean Murray, Stephen Hsu, Jeffrey Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.

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Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu Oct 2012

Epigallocatechin-3-Gallate Modulates Oxidative Stress In Exocrine Glands Of A Primary Sjogren’S Syndrome Mouse Model Prior To Disease Onset, Seiji Ohno, Hongfang Yu, Douglas Dickinson, Tin-Chun Chu, Kalu Ogbureke, Scott Derossi, Tetsuya Yamamoto, Stephen Hsu

Tin-Chun Chu, Ph.D.

No abstract provided.

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The Molecular Basis Of Drug Resistance Against Hepatitis C Virus Ns3/4a Protease Inhibitors, Keith Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Aysegul Ozen, Laura Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos Petropoulos, Wei Huang, Celia Schiffer Oct 2012

The Molecular Basis Of Drug Resistance Against Hepatitis C Virus Ns3/4a Protease Inhibitors, Keith Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Aysegul Ozen, Laura Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos Petropoulos, Wei Huang, Celia Schiffer

Celia A. Schiffer

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcomes have recently been improved by the combination therapy now including boceprevir and telaprevir, which inhibit the viral NS3/4A protease. Despite extensive efforts to develop more potent next-generation protease inhibitors, however, the long-term efficacy of this drug class is challenged by the rapid emergence of resistance. Single-site mutations at protease residues R155, A156 and D168 confer …

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Microbial Sunscreens: Opportunities And Obstacles, Tanya Soule Sep 2012

Microbial Sunscreens: Opportunities And Obstacles, Tanya Soule

Tanya Soule

No abstract provided.

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Accumulation Of Extracellular Carbohydrates In A Scytonemin-Deficient Mutant Of Nostoc Punctiforme Exposed To Uva Stress, Tanya Soule Jul 2012

Accumulation Of Extracellular Carbohydrates In A Scytonemin-Deficient Mutant Of Nostoc Punctiforme Exposed To Uva Stress, Tanya Soule

Tanya Soule

No abstract provided.

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Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus Jul 2012

Protamine-Like Proteins In 12 Sequenced Species Of Drosophila, Zain Alvi, Tin-Chun Chu, Valerie Schawaroch, Angela Klaus

Tin-Chun Chu, Ph.D.

No abstract provided.

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Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu Jun 2012

Identification And Bioinformatic Analyses Of Vanillate Operon In Cyanobacterium Synechococcus Sp. Iu 625, Robert Newby, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.

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Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu Jun 2012

Bioinformatic Analysis Of Cyanobacterial Mercuric Resistance Genes And Identification Of Synechococcus Sp. Iu 625 Putative Mercuric Resistance Genes, Lee Lee, Chiedozie Okafor, Matthew Rienzo, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

No abstract provided.

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Bacteria And Fungi Cultured From Sand, Cloacal Fluids, And Unhatched Eggs Of Olive Ridley Sea Turtles And Standard Testing Of Antimicrobial Properties Of Cloacal Fluids, Erin Keene, Tanya Soule, Frank Paladino Mar 2012

Bacteria And Fungi Cultured From Sand, Cloacal Fluids, And Unhatched Eggs Of Olive Ridley Sea Turtles And Standard Testing Of Antimicrobial Properties Of Cloacal Fluids, Erin Keene, Tanya Soule, Frank Paladino

Tanya Soule

No abstract provided.

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Investigation Of The Relationship Between Extracellular Slime Layer And Sunscreen Production In Nostoc Punctiforme, Pavan Paten, Dexter Shipe, Tanya Soule Mar 2012

Investigation Of The Relationship Between Extracellular Slime Layer And Sunscreen Production In Nostoc Punctiforme, Pavan Paten, Dexter Shipe, Tanya Soule

Tanya Soule

No abstract provided.

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Phylogenetics Of Morus (Moraceae) Inferred From Its And Trnl-Trnf Sequence Data., Madhav Nepal Mar 2012

Phylogenetics Of Morus (Moraceae) Inferred From Its And Trnl-Trnf Sequence Data., Madhav Nepal

Madhav Nepal

Morus (Tribe Moreae, Moraceae) consists of ca. 13 species of trees distributed in Asia, Africa, Europe, and North, Central, and South America. The broad geographical distribution of the genus, overlapping ranges of many taxa, and documented hybridization between some species present interesting questions of taxonomy, phylogeny, and biogeography. Phylogenetic data for Morus also contribute to higher level taxonomic work in the family. We used sequence data from ITS of the nrDNA and the chloroplast trnL-trnF intergenic spacer to study phylogenetic relationships of Morus. Phylogenies based on separate data sets were not statistically incongruent, and the combined tree …

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Bacteria And Fungi Cultured From Sand, Cloacal Fluids, And Unhatched Eggs Of Olive Ridley Sea Turtles And Standard Testing Of Antimicrobial Properties Of Cloacal Fluids, Erin Keene, Tanya Soule, Frank Paladino Feb 2012

Bacteria And Fungi Cultured From Sand, Cloacal Fluids, And Unhatched Eggs Of Olive Ridley Sea Turtles And Standard Testing Of Antimicrobial Properties Of Cloacal Fluids, Erin Keene, Tanya Soule, Frank Paladino

Tanya Soule

No abstract provided.

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