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Full-Text Articles in Genetics and Genomics
A Summary Of Current Research Into Neurodegenerative Disorders Using Drosophila Melanogaster, Chase Cortese
A Summary Of Current Research Into Neurodegenerative Disorders Using Drosophila Melanogaster, Chase Cortese
Honors Theses
Neurodegenerative disorders such as Alzheimer’s disease are characterized by damage to neural cells causing widespread neurological deficits. Historically, these diseases were deemed as inevitable declines in cognitive and neurological function that occurred with aging. Recent research has revealed, however, that these diseases have molecular bases allowing potential clinical intervention. The groundbreaking discoveries have been made using differing model organisms, which can replicate the phenotype and physiological cause of these disorders. One major model organism that has been used is the fruit fly, Drosophila melanogaster. They have served various roles in elucidating gene pathways and neurophysiological bases seen in these diseases. …
Apoe As A Metabolic Regulator In Humans, Mice, And Astrocytes, Brandon C. Farmer
Apoe As A Metabolic Regulator In Humans, Mice, And Astrocytes, Brandon C. Farmer
Theses and Dissertations--Physiology
Altered metabolic pathways appear to play central roles in the pathophysiology of late-onset Alzheimer’s disease (AD). Carrier status of the E4 allele of the APOE gene is the strongest genetic risk factor for late-onset AD, and increasing evidence suggests that E4 carriers may be at an increased risk for neurodegeneration based on inherent metabolic impairments. A new appreciation is forming for the role of APOE in cerebral metabolism, and how nutritional factors may impact this role. In chapter 1, the literature on nutritional interventions in E4 carriers aimed at mitigating disease risk is reviewed. Studies investigating the mechanism by which …