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Full-Text Articles in Genetics and Genomics
Gene Regulation And Cell Fate Choice In The Developing Vertebrate Retina, Sruti Patoori
Gene Regulation And Cell Fate Choice In The Developing Vertebrate Retina, Sruti Patoori
Dissertations, Theses, and Capstone Projects
The diverse neuronal cell types in the vertebrate retina all originate from multipotent retinal progenitor cells (RPCs). These undergo a series of molecular changes driven by developmental gene regulatory networks (GRNs) as they divide to generate RPCs which are more restricted in their potential fates. It is crucial to understand these GRNs and changes to gene expression in order to understand how cell identity is established during retinal development. In particular, the GRN that promotes the development of cone photoreceptors and horizontal cells is not well-defined. This work focuses on two approaches to further elucidate the components of this regulatory …