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- Noncoding RNA (2)
- AS1 (1)
- AS2 (1)
- BOB1 (1)
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- Breast cancer (1)
- Cancer biology (1)
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- Chromatin instability (1)
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- FIL (1)
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- Molecular cytology (1)
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- Nuclear structure (1)
- NudC (1)
- Pericentric heterochromatin (1)
- Plant development (1)
- Polycomb proteins (1)
- Proteasome (1)
- Proteostasis (1)
- Satellite heterochromatin (1)
Articles 1 - 23 of 23
Full-Text Articles in Genetics and Genomics
Ectopic Expression Of Pericentric Hsatii Rna Results In Nuclear Rna Accumulation, Mecp2 Recruitment, And Cell Division Defects, C. C. Landers, C. A. Rabeler , '20, E. K. Ferrari, Lia R. D'Alessandro , '21, D. D. Kang, J. Malisa, Safia M. Bashir , '20, Dawn M. Carone
Ectopic Expression Of Pericentric Hsatii Rna Results In Nuclear Rna Accumulation, Mecp2 Recruitment, And Cell Division Defects, C. C. Landers, C. A. Rabeler , '20, E. K. Ferrari, Lia R. D'Alessandro , '21, D. D. Kang, J. Malisa, Safia M. Bashir , '20, Dawn M. Carone
Biology Faculty Works
Within the pericentric regions of human chromosomes reside large arrays of tandemly repeated satellite sequences. Expression of the human pericentric satellite HSATII is prevented by extensive heterochromatin silencing in normal cells, yet in many cancer cells, HSATII RNA is aberrantly expressed and accumulates in large nuclear foci in cis. Expression and aggregation of HSATII RNA in cancer cells is concomitant with recruitment of key chromatin regulatory proteins including methyl-CpG binding protein 2 (MeCP2). While HSATII expression has been observed in a wide variety of cancer cell lines and tissues, the effect of its expression is unknown. We tested the effect …
Arabidopsis Heat Shock Granules Exhibit Dynamic Cellular Behavior And Can Form In Response To Protein Misfolding In The Absence Of Elevated Temperatures, Rosalie Lawrence , '12, Nicholas J. Kaplinsky
Arabidopsis Heat Shock Granules Exhibit Dynamic Cellular Behavior And Can Form In Response To Protein Misfolding In The Absence Of Elevated Temperatures, Rosalie Lawrence , '12, Nicholas J. Kaplinsky
Biology Faculty Works
No abstract provided.
Probing The Function Of Long Noncoding Rnas In The Nucleus, Sajal Medha K. Akkipeddi , '20, A. J. Velleca, Dawn M. Carone
Probing The Function Of Long Noncoding Rnas In The Nucleus, Sajal Medha K. Akkipeddi , '20, A. J. Velleca, Dawn M. Carone
Biology Faculty Works
The nucleus is a highly organized and dynamic environment where regulation and coordination of processes such as gene expression and DNA replication are paramount. In recent years, noncoding RNAs have emerged as key participants in the regulation of nuclear processes. There are a multitude of functional roles for long noncoding RNA (lncRNA), mediated through their ability to act as molecular scaffolds bridging interactions with proteins, chromatin, and other RNA molecules within the nuclear environment. In this review, we discuss the diversity of techniques that have been developed to probe the function of nuclear lncRNAs, along with the ways in which …
Illumination Pattern Design With Deep Learning For Single-Shot Fourier Ptychographic Microscopy, Yi Fei Cheng , '21, Megan Strachan , '21, Zachary Weiss , '20, Moniher Deb , '19, Dawn M. Carone, Vidya Ganapati
Illumination Pattern Design With Deep Learning For Single-Shot Fourier Ptychographic Microscopy, Yi Fei Cheng , '21, Megan Strachan , '21, Zachary Weiss , '20, Moniher Deb , '19, Dawn M. Carone, Vidya Ganapati
Biology Faculty Works
Fourier ptychographic microscopy allows for the collection of images with a high space-bandwidth product at the cost of temporal resolution. In Fourier ptychographic microscopy, the light source of a conventional widefield microscope is replaced with a light-emitting diode (LED) matrix, and multiple images are collected with different LED illumination patterns. From these images, a higher-resolution image can be computationally reconstructed without sacrificing field-of-view. We use deep learning to achieve single-shot imaging without sacrificing the space-bandwidth product, reducing the acquisition time in Fourier ptychographic microscopy by a factor of 69. In our deep learning approach, a training dataset of high-resolution images …
Genetic Interactions Between Bob1 And Multiple 26s Proteasome Subunits Suggest A Role For Proteostasis In Regulating Arabidopsis Development, Elan W. Silverblatt-Buser , '12, Melissa A. Frick , '12, C. Rabeler, Nicholas J. Kaplinsky
Genetic Interactions Between Bob1 And Multiple 26s Proteasome Subunits Suggest A Role For Proteostasis In Regulating Arabidopsis Development, Elan W. Silverblatt-Buser , '12, Melissa A. Frick , '12, C. Rabeler, Nicholas J. Kaplinsky
Biology Faculty Works
Protein folding and degradation are both required for protein quality control, an essential cellular activity that underlies normal growth and development. We investigated how BOB1, an Arabidopsis thaliana small heat shock protein, maintains normal plant development. bob1 mutants exhibit organ polarity defects and have expanded domains of KNOX gene expression. Some of these phenotypes are ecotype specific suggesting that other genes function to modify them. Using a genetic approach we identified an interaction between BOB1 and FIL, a gene required for abaxial organ identity. We also performed an EMS enhancer screen using the bob1-3 allele to identify pathways that are …
Demethylated Hsatii Dna And Hsatii Rna Foci Sequester Prc1 And Mecp2 Into Cancer-Specific Nuclear Bodies, L. L. Hall, M. Byron, Dawn M. Carone, T. W. Whitfield, G. P. Pouliot, A. Fischer, P. Jones, J. B. Lawrence
Demethylated Hsatii Dna And Hsatii Rna Foci Sequester Prc1 And Mecp2 Into Cancer-Specific Nuclear Bodies, L. L. Hall, M. Byron, Dawn M. Carone, T. W. Whitfield, G. P. Pouliot, A. Fischer, P. Jones, J. B. Lawrence
Biology Faculty Works
This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two types of cancer-specific nuclear bodies, caused by locus-specific deregulation of HSATII. DNA demethylation at the 1q12 mega-satellite, common in cancer, causes PRC1 aggregation into prominent Cancer-Associated Polycomb (CAP) bodies. These loci remain silent, whereas HSATII loci with reduced PRC1 become derepressed, reflecting imbalanced distribution of UbH2A on these and other PcG-regulated loci. Large nuclear foci of HSATII RNA form and sequester copious MeCP2 …
Review Of "A Primer Of Human Genetics" By G. Gibson, John B. Jenkins
Review Of "A Primer Of Human Genetics" By G. Gibson, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "The Least Likely Man: Marshall Nirenberg And The Discovery Of The Genetic Code" By F. H. Portugal, John B. Jenkins
Review Of "The Least Likely Man: Marshall Nirenberg And The Discovery Of The Genetic Code" By F. H. Portugal, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Race Unmasked: Biology And Race In The Twentieth Century" By M. Yudell, John B. Jenkins
Review Of "Race Unmasked: Biology And Race In The Twentieth Century" By M. Yudell, John B. Jenkins
Biology Faculty Works
No abstract provided.
An Inquiry-Infused Introductory Biology Laboratory That Integrates Mendel's Pea Phenotypes With Molecular Mechanisms, Philip Kudish, E. Schlag, Nicholas J. Kaplinsky
An Inquiry-Infused Introductory Biology Laboratory That Integrates Mendel's Pea Phenotypes With Molecular Mechanisms, Philip Kudish, E. Schlag, Nicholas J. Kaplinsky
Biology Faculty Works
We developed a multi-week laboratory in which college-level introductory biology students investigate Mendel's stem length phenotype in peas. Students collect, analyze and interpret convergent evidence from molecular and physiological techniques. In weeks 1 and 2, students treat control and experimental plants with Gibberellic Acid (GA) to determine whether uncharacterized short mutant lines are GA responsive. These data allow students to place the mutation in the GA signal transduction pathway. During weeks 2 and 3, plants are genotyped for Mendel's "le" mutation using a derived cleaved polymorphic sequences (dCAPS) PCR assay. This laboratory allows students to make a direct connection between …
Review Of "The Pku Paradox: A Short History Of A Genetic Disease" By D. B. Paul And J. P. Brosco, John B. Jenkins
Review Of "The Pku Paradox: A Short History Of A Genetic Disease" By D. B. Paul And J. P. Brosco, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Translational Stem Cell Research: Issues Beyond The Debate On The Moral Status Of The Human Embryo" Edited By K. Hug And G. Hermerén, John B. Jenkins
Review Of "Translational Stem Cell Research: Issues Beyond The Debate On The Moral Status Of The Human Embryo" Edited By K. Hug And G. Hermerén, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Fifty Animals That Changed The Course Of History" By E. Chaline, John B. Jenkins
Review Of "Fifty Animals That Changed The Course Of History" By E. Chaline, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Plant Exploration For Longwood Gardens" By T. Aniśko, Nicholas J. Kaplinsky
Review Of "Plant Exploration For Longwood Gardens" By T. Aniśko, Nicholas J. Kaplinsky
Biology Faculty Works
No abstract provided.
Review Of "Illuminating Life: Selected Papers From Cold Spring Harbor (1903-1969). Volume 1" By J. Witkowski, John B. Jenkins
Review Of "Illuminating Life: Selected Papers From Cold Spring Harbor (1903-1969). Volume 1" By J. Witkowski, John B. Jenkins
Biology Faculty Works
No abstract provided.
The Paradigm Of Huntington Disease, John B. Jenkins, P. M. Conneally
The Paradigm Of Huntington Disease, John B. Jenkins, P. M. Conneally
Biology Faculty Works
No abstract provided.
Review Of "The Nature And Origin Of The Biological World" By E. J. Ambrose, John B. Jenkins
Review Of "The Nature And Origin Of The Biological World" By E. J. Ambrose, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Case Studies In Genetics" By M. A. Tribe, I. Tallan, And M. R. Eraut, John B. Jenkins
Review Of "Case Studies In Genetics" By M. A. Tribe, I. Tallan, And M. R. Eraut, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "Introduction To Biometrical Genetics" By K. Mather And J. L. Jinks, John B. Jenkins
Review Of "Introduction To Biometrical Genetics" By K. Mather And J. L. Jinks, John B. Jenkins
Biology Faculty Works
No abstract provided.
Origins Of Biological Thought, John B. Jenkins
Origins Of Biological Thought, John B. Jenkins
Biology Faculty Works
No abstract provided.
Review Of "History Of The Life Sciences. An Annotated Bibliography" By P. Smit, John B. Jenkins
Review Of "History Of The Life Sciences. An Annotated Bibliography" By P. Smit, John B. Jenkins
Biology Faculty Works
No abstract provided.
Attitudes On Population Crisis At A Small Liberal-Arts College, John B. Jenkins, R. C. Mitchell
Attitudes On Population Crisis At A Small Liberal-Arts College, John B. Jenkins, R. C. Mitchell
Biology Faculty Works
No abstract provided.
Spontaneous Mutation Rate In The Dumpy Region Of Drosophila, John B. Jenkins
Spontaneous Mutation Rate In The Dumpy Region Of Drosophila, John B. Jenkins
Biology Faculty Works
No abstract provided.