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Full-Text Articles in Genetics and Genomics
The Α-Glycerophosphate Cycle In Drosophila Melanogaster Iv. Metabolic, Ultrastructural, And Adaptive Consequences Of Αgpdh-1 "Null" Mutations, Stephen J. O'Brien, Yoshio Shimada
The Α-Glycerophosphate Cycle In Drosophila Melanogaster Iv. Metabolic, Ultrastructural, And Adaptive Consequences Of Αgpdh-1 "Null" Mutations, Stephen J. O'Brien, Yoshio Shimada
Biology Faculty Articles
"Null" mutations previously isolated at the αGpdh-1 locus of Drosophila melanogaster, because of disruption of the energy-producing α-glycerophosphate cycle, severely restrict the flight ability and relative viability of affected individuals. Two "null" alleles, αGpdh-1BO-1-4, and αGpdh-1BO-1-5, when made hemizygous with a deficiency of the αGpdh-1 locus,Df(2L)GdhA, were rendered homozygous by recombination with and selective elimination of the Df(2L)GdhA chromosome. After over 25 generations, a homozygous αGpdh-1BO-1-4stock regained the ability to fly despite the continued absence of …
The Α-Glycerophosphate Cycle In Drosophila Melanogaster. Iii. Relative Viability Of "Null" Mutants At The Α-Glycerophosphate Dehydrogenase-1 Locus, Stephen J. O'Brien, Bruce Wallace, Ross J. Macintyre
The Α-Glycerophosphate Cycle In Drosophila Melanogaster. Iii. Relative Viability Of "Null" Mutants At The Α-Glycerophosphate Dehydrogenase-1 Locus, Stephen J. O'Brien, Bruce Wallace, Ross J. Macintyre
Biology Faculty Articles
No abstract provided.
An Analysis Of Gene-Enzyme Variability In Natural Populations Of Drosophila Melanogaster And D. Simulans, Stephen J. O'Brien, Ross J. Macintyre
An Analysis Of Gene-Enzyme Variability In Natural Populations Of Drosophila Melanogaster And D. Simulans, Stephen J. O'Brien, Ross J. Macintyre
Biology Faculty Articles
Nine populations of D. melanogaster and two populations of D. simulans were analyzed for polymorphism in 10 gene-enzyme systems by the technique of gel electrophoresis. In the eight natural populations of D. melanogaster, an average of 54% of the enzymes were polymorphic, and the average heterozygosity was 22.7%. An experimental population of D. melanogaster, which has been maintained in a laboratory cage for 20 years, showed levels of polymorphism equivalent to those of natural populations. The D. simulans populations had much less variability. The possible factors involved in maintaining these polymorphisms are discussed.