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Full-Text Articles in Genetics and Genomics
Regulation Of A Messenger: Raising Oskar, It Takes A Village, Livia V. Bayer
Regulation Of A Messenger: Raising Oskar, It Takes A Village, Livia V. Bayer
Dissertations, Theses, and Capstone Projects
D. melanogaster oogenesis serves as an excellent system to study the life of an mRNA. Tremendous work has been done to understand the numerous complex mechanisms of mRNA regulation, still there is still so much that is yet to be discovered. In this thesis, I present studies I carried out to address several aspects of oskar mRNA post-transcriptional regulation. Leading me to extend our current understanding of the carefully controlled regulation of oskar mRNA life cycle via a myriad of proteins. I found that a specific NPC component, Nup154 is necessary not only for its export from the nucleus, but …
The Roles Of Polar Cell Extensions In Drosophila Micropyle Formation, Bradford Hull
The Roles Of Polar Cell Extensions In Drosophila Micropyle Formation, Bradford Hull
Theses and Dissertations--Biology
The Drosophila micropyle is a conserved formation utilized to allow sperm passage past the robust eggshell structure for fertilization. Micropyle formation follows a unique acellular tubulogenesis method where it is secreted and shaped by specialized follicle cells including the border cells and polar cells. In late oogenesis, the polar cells form extensions that are necessary to create the micropyle pore through which sperm enters. Previous work established that polar cell extension presence is required for micropyle pore formation. We investigated temporal requirements of extensions throughout chorion deposition and found extensions are required during the beginning and middle of choriogenesis, but …