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Full-Text Articles in Genetics and Genomics
Integrated Regulation Of Class Ii Human Endogenous Retroviruses In A Breast Cancer Cell Line, Yingguang Liu, Tam D. Nguyen
Integrated Regulation Of Class Ii Human Endogenous Retroviruses In A Breast Cancer Cell Line, Yingguang Liu, Tam D. Nguyen
Proceedings of the International Conference on Creationism
Endogenous retroviruses (ERVs) are still regarded as foreign invaders by most biologists. Because of structural and positional homology of ERVs in human and ape genomes, they have been considered molecular evidences of common ancestry. Using a breast cancer cell line, we analyzed the regulatory features of a group of human endogenous retroviruses (HERV-K), and found that they contain multiple sequence motifs subjecting them to regulation by sex hormones, a stem cell-specific transcription factor (OCT4), and DNA methylation. Mutation of the OCT4 motif abrogates their response to sex hormones, while methylation of a progesterone-response element enhances receptor-binding. We also found that …
Killi-Data News (Winter), Tyrone Genade
Killi-Data News (Winter), Tyrone Genade
Killifish Research Review
Valued readers, it is with a heavy heart that I inform you that this is the last issue of Killi-Data News. The good news is that we will be back as Killifish Research Review. The dissolution of Killi-Data International created a prob- lem: how can the newsletter of a defunct organization live on without that organization? But other additional problems were building in the background. The first issue numbered 15 pages. The previous issue was 28 pages. The number of killifish related papers is increasing while time on our end (the editorial team) is running out. It takes a lot …
Killi-Data News (Fall), Tyrone Genade
Killi-Data News (Fall), Tyrone Genade
Killifish Research Review
Many interesting papers have been published over the last three months. The large volume of papers coupled with the start of the new college semester (and the workload it brings) delayed this issue of Killi-Data News. But better late than never—or so I hope! In this issue Richard van der Laan provides an insightful review of the recent Aphanius papers as to their taxonomic implications and questions. The systematic issues he raises show the importance of the Molecular project: we need to get more samples of the various cyprinodontiforme families to resolve unsettled systematic and taxonomic issues. In the Next …
Killi-Data News (Summer), Tyrone Genade
Killi-Data News (Summer), Tyrone Genade
Killifish Research Review
Over the last three months several interesting and exciting pa- pers have been published. By now most of you have heard the Nothobranchius fish poo news emanating from the Valenzano lab. That paper is reviewed and certainly has repercussions for the health of our captive fish. Polaçik et al have published interesting data with ramifications as to how we breed and incubate annual killifish. The big news in this issue is the paper from the Reznick lab which Jean Huber reviews. The contents of that paper goes to the heart of the question of just what a killifish is. The …
Killi-Data News (Spring), Tyrone Genade
Killi-Data News (Spring), Tyrone Genade
Killifish Research Review
This is the start of Killi-Data News’ second year. In this first issue of the year we have the usual review of research pub- lications as well as input from Martin Reichard on his lab’s Nothobranchius research. Martin is responding to my reviews of his lab’s work in the previous edition. I am serious about making sure the content in this newsletter is reliable but I erred in the previous edition and Martin has written extensively to correct my mistake in the section “Erratum”. This reply is welcomed and owed to readers. I must confess that I don’t know everything …
Killi-Data News (Winter), Tyrone Genade
Killi-Data News (Winter), Tyrone Genade
Killifish Research Review
This is the fourth edition, and concluding issue of the first volume, of Killi-Data News and I am happy that it has been well received by readers. At 25 pages this issue is a bit thin- ner than the last but this is because we agreed to make the cut-off for submissions the 1 st of December so we could get this edition out by the New Year. This is an exciting edition full of new species descrip- tions and analyses that will keep taxonomists busy for years to come. Costa has given us two molecular phylogenies on Melanorivulus as …
Killi-Data News (Spring), Tyrone Genade
Killi-Data News (Spring), Tyrone Genade
Killifish Research Review
This is the start of Killi-Data News’ second year. In this first issue of the year we have the usual review of research pub- lications as well as input from Martin Reichard on his lab’s Nothobranchius research. Martin is responding to my reviews of his lab’s work in the previous edition. I am serious about making sure the content in this newsletter is reliable but I erred in the previous edition and Martin has written extensively to correct my mistake in the section “Erratum”. This reply is welcomed and owed to readers. I must confess that I don’t know everything …
Why Doesn’T A Mother Reject A Genetically Different Fetus?, Devora Krumholtz
Why Doesn’T A Mother Reject A Genetically Different Fetus?, Devora Krumholtz
The Science Journal of the Lander College of Arts and Sciences
Many basic multicellular organisms possess some form of immune response to protect themselves against the invasion of foreign objects. It was not until British scientist, Peter Medawar proposed a fundamental question that changed the way researchers studied the maternofetal relationship. A fetus, being genetically different from its mother should be rejected by the maternal immune system, however, it is not. Researchers have since discovered and developed several mechanisms that aim to explain how the maternal immune system prevents fetal rejection. The formation of a mechanical barrier, general and local suppression of the maternal immune system, and a shift in cytokine …