Open Access. Powered by Scholars. Published by Universities.®
City University of New York (CUNY)
Dissertations, Theses, and Capstone Projects
Might impair the phase separation properties of the protein and impact its pathological role in cells. I first tested the effect of single amino acid substitutions in vitro
Articles 1 - 1 of 1
Full-Text Articles in Genetics and Genomics
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Dissertations, Theses, and Capstone Projects
Tau is a protein expressed exclusively in glia and neurons in the central nervous system and implicated in several neurogenerative diseases called “tauopathies”. Among all the tauopathies, one third is characterized by the presence of genetic mutations leading to the synthesis of tau proteins with single amino acid substitutions at specific locations and affecting protein function. While most of the initial studies have emphasize the functional role of tau as modulator of the axonal cytoskeleton, it has recently been well accepted that tau is also an intrinsically disordered protein that tends to form membraneless organelles called coacervates, due to a …