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- Lipogenesis (3)
- Lipolysis (2)
- Metabolic switch (2)
- Microarray analysis (2)
- Acetyl CoA deficiency (1)
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- Adiposity (1)
- Chicken flavoproteome (1)
- Coagulation factors (1)
- Coagulation system (1)
- Divergent genetic selection (1)
- Endocrine signaling (1)
- Expression profiling (1)
- Feather keratin (1)
- Gene expression (1)
- Gene interaction networks (1)
- Hemostasis genes (1)
- Hepatic FKER (1)
- Homeorhesis (1)
- Homeorhetric regulation of metabolism (1)
- Impaired lipid metabolism (1)
- Kruppel-like factors (1)
- Lipid metabolism (1)
- Opposing up-stream regulators (1)
- Protease inhibitors (1)
- Protein catabolism (1)
- RNA-Seq analysis (1)
- Reciprocal inhibition/activation (1)
- Riboflavin deficiency (1)
- SERTAD2 (1)
- Spot 14 (THRSPA) (1)
Articles 1 - 4 of 4
Full-Text Articles in Genetics and Genomics
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Biology Faculty Research
Background
The fasting-refeeding perturbation has been used extensively to reveal specific genes and metabolic pathways that control energy metabolism in the chicken. Most global transcriptional scans of the fasting-refeeding response in liver have focused on juvenile chickens that were 1, 2 or 4 weeks old. The present study was aimed at the immediate post-hatch period, in which newly-hatched chicks were subjected to fasting for 4, 24 or 48 h, then refed for 4, 24 or 48 h, and compared with a fully-fed control group at each age (D1-D4).
Results
Visual analysis of hepatic gene expression profiles using hierarchical and K-means …
Transcriptional Profiling Of Liver During The Critical Embryo-To-Hatchling Transition Period In The Chicken (Gallus Gallus), Larry A. Cogburn, Nares Trakooljul, Chuming Chen, Hongzhan Huang, Cathy H. Wu, Wilfrid Carré, Xiaofei Wang, Harold B. White Iii
Transcriptional Profiling Of Liver During The Critical Embryo-To-Hatchling Transition Period In The Chicken (Gallus Gallus), Larry A. Cogburn, Nares Trakooljul, Chuming Chen, Hongzhan Huang, Cathy H. Wu, Wilfrid Carré, Xiaofei Wang, Harold B. White Iii
Biology Faculty Research
Background
Although hatching is perhaps the most abrupt and profound metabolic challenge that a chicken must undergo; there have been no attempts to functionally map the metabolic pathways induced in liver during the embryo-to-hatchling transition. Furthermore, we know very little about the metabolic and regulatory factors that regulate lipid metabolism in late embryos or newly-hatched chicks. In the present study, we examined hepatic transcriptomes of 12 embryos and 12 hatchling chicks during the peri-hatch period—or the metabolic switch from chorioallantoic to pulmonary respiration.
Results
Initial hierarchical clustering revealed two distinct, albeit opposing, patterns of hepatic gene expression. Cluster A genes …
Transcriptional Profiling Of Liver In Riboflavin-Deficient Chicken Embryos Explains Impaired Lipid Utilization, Energy Depletion, Massive Hemorrhaging, And Delayed Feathering, Larry A. Cogburn, Danielle N. Smarsh, Xiaofei Wang, Nares Trakooljul, Wilfrid Carré, Harold B. White Iii
Transcriptional Profiling Of Liver In Riboflavin-Deficient Chicken Embryos Explains Impaired Lipid Utilization, Energy Depletion, Massive Hemorrhaging, And Delayed Feathering, Larry A. Cogburn, Danielle N. Smarsh, Xiaofei Wang, Nares Trakooljul, Wilfrid Carré, Harold B. White Iii
Biology Faculty Research
Background
A strain of Leghorn chickens (rd/rd), unable to produce a functional riboflavin-binding protein, lays riboflavin-deficient eggs, in which all embryos suddenly die at mid-incubation (days 13-15). This malady, caused by riboflavin deficiency, leads to excessive lipid accumulation in liver, impaired β-oxidation of lipid, and severe hypoglycemia prior to death. We have used high-density chicken microarrays for time-course transcriptional scans of liver in chicken embryos between days 9-15 during this riboflavin-deficiency-induced metabolic catastrophe. For comparison, half of rd/rd embryos (n = 16) were rescued from this calamity by injection of riboflavin just prior to incubation of fertile …
Transcriptional Analysis Of Abdominal Fat In Chickens Divergently Selected On Bodyweight At Two Ages Reveals Novel Mechanisms Controlling Adiposity: Validating Visceral Adipose Tissue As A Dynamic Endocrine And Metabolic Organ, Christopher W. Resnyk, Wilfrid Carré, Xiaofei Wang, Tom E. Porter, J. Simon, Elisabeth Le Bihan-Duval, Michel J. Duclos, Sammy E. Aggrey, Larry A. Cogburn
Transcriptional Analysis Of Abdominal Fat In Chickens Divergently Selected On Bodyweight At Two Ages Reveals Novel Mechanisms Controlling Adiposity: Validating Visceral Adipose Tissue As A Dynamic Endocrine And Metabolic Organ, Christopher W. Resnyk, Wilfrid Carré, Xiaofei Wang, Tom E. Porter, J. Simon, Elisabeth Le Bihan-Duval, Michel J. Duclos, Sammy E. Aggrey, Larry A. Cogburn
Biology Faculty Research
Background
Decades of intensive genetic selection in the domestic chicken (Gallus gallus domesticus) have enabled the remarkable rapid growth of today’s broiler (meat-type) chickens. However, this enhanced growth rate was accompanied by several unfavorable traits (i.e., increased visceral fatness, leg weakness, and disorders of metabolism and reproduction). The present descriptive analysis of the abdominal fat transcriptome aimed to identify functional genes and biological pathways that likely contribute to an extreme difference in visceral fatness of divergently selected broiler chickens.
Methods
We used the Del-Mar 14 K Chicken Integrated Systems microarray to take time-course snapshots of global gene transcription …