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Behavioral, Environmental, Metabolic And Intergenerational Components Of Early Life Undernutrition Leading To Later Obesity In Developing Nations And In Minority Groups In The Usa, Maria I. Varela-Silva, A. Roberto Frisancho, Berry Bogin, David Chatkoff, Patricia K. Smith, Federico Dickinson, Donna Winham

Donna Winham

Nutritional transition, urbanization, and physical inactivity are primary factors responsible for the worldwide epidemic of overweight/obesity (OW/OB). However, these factors fail to explain the epidemic of OW/OB in developing countries and in recent-migrants to developed countries. Among these, OW/OB is associated with short/stunted stature and coexists with undernutrition at much higher rates than is statistically expected. Changes in metabolic pathways toward reduced fat oxidation and increased metabolism of carbohydrate may explain, in part, this phenomenon. Also, intergenerational consequences of malnutrition and poor health of the others may lead to impaired phenotypes in their offspring. We propose a novel methodology to …