Food Science Commons^™

Dietary Selenium Affects Host Selenoproteome Expression By Influencing The Gut Microbiota, Marina V. Kasaikina, Marina A. Kravtsova, Byung Cheon Lee, Javier Seravalli, Daniel A. Peterson, Jens Walter, Ryan Legge, Andrew K. Benson, Dolph L. Hatfield, Vadim Gladyshev

Department of Food Science and Technology: Faculty Publications

Colonization of the gastrointestinal tract and composition of the microbiota may be influenced by components of the diet, including trace elements. To understand how selenium regulates the intestinal microflora, we used high-throughput sequencing to examine the composition of gut microbiota of mice maintained on selenium-deficient, selenium-sufficient, and selenium-enriched diets. The microbiota diversity increased as a result of selenium in the diet. Specific phylotypes showed differential effects of selenium, even within a genus, implying that selenium had unique effects across microbial taxa. Conventionalized germfree mice subjected to selenium diets gave similar results and showed an increased diversity of the bacterial population …