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- Keyword
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- Adiponectin (1)
- Aflatoxin B1 (1)
- Amphiphilic; Aristolochic acids; Ionization; Magnetic copolymer; Traditional Chinese patent medicines (1)
- Annatto (1)
- Anti-angiogenesis (1)
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- Anti-inflammation (1)
- Anti-tumor (1)
- Antioxidant (1)
- Antityrosinase (1)
- Arbutus unedo (1)
- Attenuated total reflection−Fourier transform infrared spectroscopy (ATR–FTIR) (1)
- Bixin; Green solvent; Wound healing (1)
- Botanicals (1)
- Cancer (1)
- Cancer diagnosis (1)
- Carbon nanodots (1)
- Cell nucleus (1)
- Chemical composition (1)
- Chili powder (1)
- Cinnamaldehyde; Cinnamon (1)
- Citrus depressa (1)
- Citrus peels (1)
- DMN-induced liver injury; Freshwater clam; Hepatic stellate cells; Liver fibrosis (1)
- Fluorescence imaging (1)
- Functional foods (1)
- Functional property; Physicochemical characteristics; Pomelo sponge layers; Soluble dietary fiber; Structure (1)
- Gallic acid (1)
- Glyoxalase-1 (1)
- Guhong injection (1)
- Gut microbiota (1)
Articles 1 - 15 of 15
Full-Text Articles in Food Science
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Journal of Food and Drug Analysis
Cell nucleus status decides the activities of corresponding cells, making its rapid and effective staining important for revealing the actual condition of biological environment in life science and related fields. In this study, fast staining of cell nucleus is realized by fluorescent carbon nanodots (CDs). The staining mechanism is due to the positively charged CD surface-induced cell membrane penetration, which facilitates the CD-nucleus binding via electrostatic attraction. The size of cell nucleus is easily measured with fluorescence imaging technique. In addition, the CD-based cell nucleus stain is applied for discriminating the normal and cancer cells by determining the cell-to-nucleus ratio …
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Journal of Food and Drug Analysis
We aimed to investigate the therapeutic potential of ibuprofen against type 2 diabetes (T2D) using obese Zucker diabetic fatty (ZDF) rats as type 2 diabetes model. ZDF rats were hyperglycemic, dyslipidemic and expressed pro-inflammatory markers in contrast to lean controls, thus reflecting the relationship between obesity and chronic inflammation promoting T2D. Chronic treatment with ibuprofen (2-(4-Isobutylphenyl)propanoic acid) was used to study the impact on pathological T2D conditions as compared to metformin (1,1-dimethylbiguanide) treated ZDF as well as lean controls. Ibuprofen decreased A1c but induced a high insulin release with improved glucose tolerance only after early time points (i.g., 15 and …
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Journal of Food and Drug Analysis
Citrus peels contain abundant polyphenols, particularly flavonoids, and have been shown to exert lipid accumulation decreasing ability. In this study, Citrus depressa peel applied to oven drying and extracted with ethanol extract as CDEE to analyze its flavonoids compositions and investigated its effects on a high-fat diet (HFD)-induced obese mice model. CDEE contained several flavonoids such as hesperidin, sinesentin, nobiletin, tangeretin, 5-demethylnobiletin, and 5-demethyltangeretin. The mice fed an HFD, and administration of 2% CDEE to could decrease weight gain, abdominal fat weight, inguinal fat weight, and the adipocyte size, and CDEE also reduced serum total cholesterol (TCHO), triacylglycerol (TG) compared …
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Journal of Food and Drug Analysis
Investigation of utilization possibilities of natural sources has been an important area for research. Tyrosinase inhibitory activity plays a key role in food and medicine industry. Strawberry tree (Arbutus unedo), a widely distributed plant among Mediterranean countries, possess fruits and leaves with rich bioactive phytochemicals, especially polyphenolic compounds. In this study, we aimed to investigate the antityrosinase activity of the fruit and leaf extracts of the plant, and to determine the phenolic compounds that contribute to the antityrosinase activity. In this regard, we evaluated the effect of solvent composition on the extraction of phenolic compounds from A. unedo …
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Journal of Food and Drug Analysis
Aflatoxin B1, a major global food safety concern, is produced by toxigenic fungi during crop growing, drying, and storage, and shows increasing annual prevalence. This study aimed to detect aflatoxin B1 in chili samples using ATR–FTIR coupled with machine learning algorithms. We found that 83.6% of the chili powder samples were contaminated with Aspergillus and Penicillium species, with aflatoxin B1 levels ranging from 7.63 to 44.32 µg/kg. ATR–FTIR spectroscopy in the fingerprint region (1800−400 cm-1) showed peak intensity variation in the bands at 1587, 1393, and 1038 cm-1, which are mostly related …
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Journal of Food and Drug Analysis
Nutraceuticals, that include food ingredients and bioactives from natural products, confer physiological health benefits and protection against chronic diseases. Annatto is a tropical shrub grown in Central and South America and parts of India. Its seeds are rich in the edible carotenoid-derived apocarotenoid pigment, bixin, which is used as a natural colorant in food, textiles, and cosmetics, and is now gaining attention for its potential health-promoting attributes. Here, we compared a green solvent (ethyl lactate) based extraction of bixin and associated metabolites in annatto seeds (crushed and seed coat) with two other conventional solvents (acetone and acid-base). Bixin was characterized …
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Journal of Food and Drug Analysis
In this study, a marine medicinal brown alga Sargassum cristaefolium-derived fungal strain Xylaria acuta SC1019 was isolated and identified. Column chromatography of the extracts from liquid- and solid-fermented products of the fungal strain was carried out, and led to the isolation of twenty-one compounds. Their structures were characterized by spectroscopic analysis, and the absolute configurations were further established by single X-ray diffraction analysis or modified Mosher’s method as nine previously undescribed compounds, namely xylarilactones A–C (1–3), ent-gedebic acid 8-O-α-D-glucopyranoside (4), 5R-hydroxylmethylmellein 11-O-α-D-glucopyranoside (5), ent …
The Role And Mechanism Of Cinnamaldehyde In Cancer, Jiahua Peng, Xin Song, Wenbin Yu, Yuhan Pan, Yufei Zhang, Hui Jian, Bin He
The Role And Mechanism Of Cinnamaldehyde In Cancer, Jiahua Peng, Xin Song, Wenbin Yu, Yuhan Pan, Yufei Zhang, Hui Jian, Bin He
Journal of Food and Drug Analysis
As cancer continues to rise globally, there is growing interest in discovering novel methods for prevention and treatment. Due to the limitations of traditional cancer therapies, there has been a growing emphasis on investigating herbal remedies and exploring their potential synergistic effects when combined with chemotherapy drugs. Cinnamaldehyde, derived from cinnamon, has gained significant attention for its potential role in cancer prevention and treatment. Extensive research has demonstrated that cinnamaldehyde exhibits promising anticancer properties by modulating various cellular processes involved in tumor growth and progression. However, challenges and unanswered questions remain regarding the precise mechanisms for its effective use as …
Trends And Current Food Safety Regulations And Policies For Functional Foods And Beverages Containing Botanicals, Jarunee Intrasook, Takuji W. Tsusaka, Anil Kumar Anal
Trends And Current Food Safety Regulations And Policies For Functional Foods And Beverages Containing Botanicals, Jarunee Intrasook, Takuji W. Tsusaka, Anil Kumar Anal
Journal of Food and Drug Analysis
Globally, the demand for functional foods and beverages has significantly increased due to socioeconomic changes, particularly in health consciousness to enhance their functionality. Functional ingredients derived from botanicals are widely used because of their phytochemical properties with health benefits. This study aims to (1) review the capabilities and challenges of botanical addition in functional foods, (2) review current policies and regulations for functional foods containing botanicals in the European Union (EU), Canada, Japan, the Republic of Korea, and Thailand, and (3) provide recommendations on effective food safety control measures for better consumer trust and trade facilitation. This critical review was …
An Acute Herb-Drug Interaction Of Magnoliae Officinalis Cortex With Methotrexate Via Inhibiting Multidrug Resistance-Associated Protein 2, Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Ying-Chen Chen, Lu-Ching Ho, Yow-Wen Hsieh, Yu-Chi Hou
An Acute Herb-Drug Interaction Of Magnoliae Officinalis Cortex With Methotrexate Via Inhibiting Multidrug Resistance-Associated Protein 2, Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Ying-Chen Chen, Lu-Ching Ho, Yow-Wen Hsieh, Yu-Chi Hou
Journal of Food and Drug Analysis
Magnoliae Officinalis Cortex (MOC), an herbal drug, contains polyphenolic lignans mainly magnolol (MN) and honokiol (HK). Methotrexate (MTX), a critical drug for cancers and autoimmune deseases, is a substrate of multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). This study investigated the effect of coadministration of MOC on the pharmacokinetics of MTX and relevant mechanisms. Sprague-Dawley rats were orally administered MTX alone and with single dose (2.0 and 4.0 g/kg) and repeated seven doses of MOC (2.0 g/kg thrice daily for 2 days, the 7th dose given at 0.5 h before MTX). The serum concentrations of MTX …
An Auxiliary Strategy Of Partial Least Squares Regression In Pharmacokinetic/Pharmacodynamic Studies: A Case Of Application Of Guhong Injection In Myocardial Ischemia/Reperfusion Rats, Hai-Yang Chen, Chang Li, Chong-Yu Shao, Yu-Jia Wu, Hai-Tong Wan, Yu He
An Auxiliary Strategy Of Partial Least Squares Regression In Pharmacokinetic/Pharmacodynamic Studies: A Case Of Application Of Guhong Injection In Myocardial Ischemia/Reperfusion Rats, Hai-Yang Chen, Chang Li, Chong-Yu Shao, Yu-Jia Wu, Hai-Tong Wan, Yu He
Journal of Food and Drug Analysis
Guhong injection (GHI) has been applied in the therapy of cardio-cerebrovascular disease in clinic, but there is no report about the pharmacokinetic/pharmacodynamic (PK/PD) research on GHI treating myocardial ischemia/reperfusion (MI/R) injury in rats. In this study, eight compounds of GHI in plasma, including N-acetyl-L-glutamine (NAG), chlorogenic acid (CGA), hydroxysafflor yellow A (HSYA), p-coumaric acid (pCA), rutin, hyperoside, kaempferol-3-O-rutinoside, and kaempferol-3-O-glucoside, were quantified by LC-MS/MS. We discovered that the values of t1/2β, k12, V2, and CL2 were larger than those of t1/2α, k21, V1, and …
Ionizable Copolymer Functionalized Magnetic Nanocomposite As An Adsorbent For Boosting The Extraction Selectivity Of Aristolochic Acids, Qi-Yue Xie, Yang Chen, Chang-Jun Li, Jia-Bin Zhang, Xiu-Jun Cao, Jun Lu
Ionizable Copolymer Functionalized Magnetic Nanocomposite As An Adsorbent For Boosting The Extraction Selectivity Of Aristolochic Acids, Qi-Yue Xie, Yang Chen, Chang-Jun Li, Jia-Bin Zhang, Xiu-Jun Cao, Jun Lu
Journal of Food and Drug Analysis
Aristolochic acid nephropathy (AAN) has drawn increasing public attention. Organic anion transporters (OATs) are considered to be responsible for mediating nephrotoxicity of aristolochic acids (AAs), as AAs are typical OAT1 substrates that exhibit anionic properties and contain one hydrophobic domain. Inspired by the OAT1 three-dimensional structure or substrate/protein interactions involved in transport, we designed a magnetic polymeric hybrid, mimicking the effect of basic and aromatic residues of OAT1, for efficient enriching aristolochic acid I (AA I) and aristolochic acid II (AA II) in Traditional Chinese patent medicines (TCPM). N, N-dimethylaminopropyl acrylamide (DMAPAm) was used as a cationic monomer and copolymerized …
Effect Of Indian Gooseberry Extract On Improving Methylglyoxal-Associated Leptin Resistance In Peripheral Tissues Of High-Fat Diet-Fed Rats, Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Effect Of Indian Gooseberry Extract On Improving Methylglyoxal-Associated Leptin Resistance In Peripheral Tissues Of High-Fat Diet-Fed Rats, Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, Gow-Chin Yen
Journal of Food and Drug Analysis
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such asvitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD). Accordingly, this study investigated the functions of WEIG and GA in inhibiting MG-induced leptin …
Pomelo (Citrus Grandis (L.) Osbeck) Sponge Layers As A Potential Source Of Soluble Dietary Fiber: Evaluation Of Its Physicochemical, Structural And Functional Properties, Xiaowei Chen, Jiajia Chen, Jian Peng, Yuanshan Yu, Jijun Wu, Jing Wen, Zhiying Kang, Yanhui Wang, Yujuan Xu, Lu Li
Pomelo (Citrus Grandis (L.) Osbeck) Sponge Layers As A Potential Source Of Soluble Dietary Fiber: Evaluation Of Its Physicochemical, Structural And Functional Properties, Xiaowei Chen, Jiajia Chen, Jian Peng, Yuanshan Yu, Jijun Wu, Jing Wen, Zhiying Kang, Yanhui Wang, Yujuan Xu, Lu Li
Journal of Food and Drug Analysis
Pomelo sponge layer (PSL) had been considered as a potential source of soluble dietary fiber (SDF), while they were mostly disposed of as waste. To promote high-value utilization of pomelo wastes, this study extracted SDF from PSL of six varieties of pomelo, and their physicochemical, structural and functional properties were investigated. Results indicated that all PSL-SDFs showed good physicochemical and functional properties. Among them, PSL-SDF from grapefruit (GRSDF) showed better water holding capacity and swelling capacity, whereas Shatian pomelo PSL-SDF and Guanxi pomelo PSL-SDF had the highest thermal stability and oil holding capacity, respectively. Furthermore, compared with other PSL-SDFs, GRSDF …
Trans-2-Nonadecyl-4-(Hydroxymethyl)-1,3-Dioxolane (Tnhd) Purified From Freshwater Clams Markedly Alleviates Dimethylnitrosamine-Induced Hepatic Fibrosis, Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan
Trans-2-Nonadecyl-4-(Hydroxymethyl)-1,3-Dioxolane (Tnhd) Purified From Freshwater Clams Markedly Alleviates Dimethylnitrosamine-Induced Hepatic Fibrosis, Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan
Journal of Food and Drug Analysis
Liver fibrosis occurs due to injury or inflammation, which results in the excessive production of collagen and the formation of fibrotic scar tissue that impairs liver function. Despite the limited treatment options available, freshwater clams may hold promise in the treatment of liver fibrosis. In this study, we demonstrated the effects of ethanol extract of freshwater clam (FCE), ethyl acetate extract of FCE (EA-FCE), and trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) on liver fibrosis induced by dimethylnitrosamine (DMN). Administration of FCE and TNHD alleviated liver injury, including tissue damage, necrosis, inflammation scores, fibrosis scores, serum enzymes, and triglyceride levels. Furthermore, we analyzed the expression …