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Cell and Developmental Biology Commons™
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Full-Text Articles in Cell and Developmental Biology
Ngly1 Deficiency Affects Glycosaminoglycan Biosynthesis And Wnt Signaling Pathway In Mice, Amy Batten
Ngly1 Deficiency Affects Glycosaminoglycan Biosynthesis And Wnt Signaling Pathway In Mice, Amy Batten
PANDION: The Osprey Journal of Research and Ideas
Individuals affected by NGLY1 Deficiency cannot properly deglycosylate and recycle certain proteins. Even though less than 100 people worldwide have been diagnosed with this rare autosomal recessive condition, thousands are affected by similar glycosylation disorders. Common phenotypic manifestations of NGLY1 Deficiency include severe neural and intellectual delay, impaired muscle and liver function, and seizures that may become intractable. Very little is currently known about the various mechanisms through which NGLY1 deficiency affects the body and this has led to a lack of viable treatment options for those afflicted. This experiment uses a loss-of-function (LOF) mouse model of NGLY1 Deficiency homologous …
The Role And Regulation Of The Caudal Gene In Tribolium Castaneum Segmentation, Suzanne Nicole Carpe Elias
The Role And Regulation Of The Caudal Gene In Tribolium Castaneum Segmentation, Suzanne Nicole Carpe Elias
Senior Theses and Projects
The embryo of the red flour beetle Tribolium castaneum develops sequentially by adding segments in an anterior-to-posterior progression using a “clock”-like mechanism similar to that of vertebrates. Previous studies indicate that the oscillations of this segmentation clock are driven by a gradient of the transcription factor caudal (cad), which activates and regulates the clock. Knocking down the cad gene using parental or early embryonic RNAi leads to animals with only head segments. We hypothesized that progressively later embryonic knockdowns would produce animals with progressively more segments if the function of cad does not change during segmentation. To examine …