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Full-Text Articles in Cell and Developmental Biology
Vegf/Neuropilin Signaling In Cancer Stem Cells, Arthur M. Mercurio
Vegf/Neuropilin Signaling In Cancer Stem Cells, Arthur M. Mercurio
Arthur M. Mercurio
The function of vascular endothelial growth factor (VEGF) in cancer extends beyond angiogenesis and vascular permeability. Specifically, VEGF-mediated signaling occurs in tumor cells and this signaling contributes to key aspects of tumorigenesis including the self-renewal and survival of cancer stem cells (CSCs). In addition to VEGF receptor tyrosine kinases, the neuropilins (NRPs) are critical for mediating the effects of VEGF on CSCs, primarily because of their ability to impact the function of growth factor receptors and integrins. VEGF/NRP signaling can regulate the expression and function of key molecules that have been implicated in CSC function including Rho family guanosine triphosphatases …
P4ha1 Is A New Regulator Of The Hif-1 Pathway In Breast Cancer, Ren Xu
P4ha1 Is A New Regulator Of The Hif-1 Pathway In Breast Cancer, Ren Xu
Markey Cancer Center Faculty Publications
Hypoxia-Inducible Factor (HIF)-1 is a transcription factor that plays the key role in response to low oxygen concentrations, or hypoxia. Activation of the HIF-1 pathway is not only crucial for normal tissue development and function, but also involved in disease progression, such as cancer. Cancer cells proliferate rapidly in solid tumors, and thus, solid tumors consume much more oxygen and nutrients than normal tissue and generate oxygen tension. It is well established that oxygen tension in solid tumor tissue induces the aberrant activation of the HIF-1 pathway, and subsequently promotes angiogenesis and tumor progression. Breast cancer is a heterogeneous disease …