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Cell and Developmental Biology Commons™
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- Bacillus subtilis (1)
- Bmi-1 RNA (1)
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- Mosaic Analysis with a Repressible Cell Marker system (MARCM) (1)
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Articles 1 - 4 of 4
Full-Text Articles in Cell and Developmental Biology
Stationary Phase Mutagenesis In Bacillus Subtilis: The Interaction Between Transcription And Error-Prone Replication In Conditions Of Stress, Mary Girard, Eduardo Robleto
Stationary Phase Mutagenesis In Bacillus Subtilis: The Interaction Between Transcription And Error-Prone Replication In Conditions Of Stress, Mary Girard, Eduardo Robleto
Undergraduate Research Opportunities Program (UROP)
While under conditions of stress, non-dividing cells may acquire beneficial mutations. This is referred to as stationary phase mutagenesis, or adaptive mutagenesis. Previous research has shown that actively transcribed genes and those under selective pressure are prone to mutations that confer escape from non-dividing conditions. Accordingly, strains lacking transcription factors have shown a drastically lower number of mutations that confer escape while under amino acid starvation than those observed in the wildtype background. Also, error-prone DNA polymerases are known to be active in cells under stress and it has been shown that strains lacking an error-prone DNA polymerase display reduced …
Pdest Fg12-Cmv Dsred Vector, Jarod Wolffis, Sheri L. Holmen
Pdest Fg12-Cmv Dsred Vector, Jarod Wolffis, Sheri L. Holmen
Undergraduate Research Opportunities Program (UROP)
Melanoma is the most rapidly increasing malignancy among young people in the United States. If detected early, the disease is easily treated; however, once the disease has metastasized it is largely refractory to conventional therapies and is associated with a high mortality rate. The development of human cancer from a pre-malignant primary tumor to a metastatic lesion that develops at secondary sites is thought to be a multi-step process, requiring many genetic and epigenetic events that provide a growth advantage to cells. It is still unclear which of the many genetic changes in human cancers are required for metastasis. Therefore, …
Expression Of An Alternate Splice Form Of Bmi-1 In Multiple Myeloma, Adam Austin, Kristine Veys, Debbie Wong, James Tung
Expression Of An Alternate Splice Form Of Bmi-1 In Multiple Myeloma, Adam Austin, Kristine Veys, Debbie Wong, James Tung
Undergraduate Research Opportunities Program (UROP)
The concept of “tumor stem cells” has garnered much attention in the last few years. Tumor stem cells are believed to exist among a heterogeneous group of cells that constitute a tumor. These tumor stem cells often express genes that are important for stem cell function, cell division, and maintenance of pluripotent state in stem cells. Stem cell or stem cell maintenance genes such as SALL 4 and Bmi-1 are often seen in these cancer cells and contribute to self-renewing divisions and cancer cell survival. In particular, high expression of Bmi-1 (B lymphoma mouse Moloney leukemia virus insertion region), a …
Role Of Ecdysone Signaling In Fat Body Remodeling, Marsha Kristel Bernardo, N. Bond, Allen G. Gibbs
Role Of Ecdysone Signaling In Fat Body Remodeling, Marsha Kristel Bernardo, N. Bond, Allen G. Gibbs
Undergraduate Research Opportunities Program (UROP)
Climate change is fundamentally connected to animal development and survival, and the life history of an organism must be coordinated with predictable seasonal changes of the environment. Climate change affects the life cycle of plants, a major food source for insects. If photoperiod, the primary environmental queue that insects utilize to determine the proper emergence time, and food availability becomes out of sync, many populations of insects and other animals could be threatened. Understanding animal development can provide insight into this issue and could provide clues that may help the scientific community predict how insect populations may respond to climate …