Cell and Developmental Biology Commons^™

Adipose Tissue Mast Cells Promote Human Adipose Beiging In Response To Cold, Brian S. Finlin, Amy L. Confides, Beibei Zhu, Mary C. Boulanger, Hasiyet Memetimin, Kyle W. Taylor, Zachary R. Johnson, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern

Internal Medicine Faculty Publications

In a recent study, repeated cold application induced beiging in subcutaneous white adipose tissue (SC WAT) of humans independent of body mass index. To identify factors that promote or inhibit beiging, we performed multiplex analysis of gene expression with the Nanostring nCounter system (the probe set contained genes for specific immune cell markers, cytokines, and chemokines) on the SC WAT from lean subjects. Multiple correlations analysis identified mast cell tryptase and CCL26, a chemokine for mast cells, as genes whose change correlated positively with the change in UCP1 in SC WAT, leading to the hypothesis that mast cells promote SC …