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Cell and Developmental Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
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Articles 1 - 5 of 5
Full-Text Articles in Cell and Developmental Biology
Protective Effects Of The Novel Phytonutrient S7 Against Intestinal Tight Junction Disruption: Composition Matters, Erin E. Olson, Alexi L. Zastrow, Daniel R. Sharda
Protective Effects Of The Novel Phytonutrient S7 Against Intestinal Tight Junction Disruption: Composition Matters, Erin E. Olson, Alexi L. Zastrow, Daniel R. Sharda
Pence-Boyce STEM Student Scholarship
The prevalence of intestinal inflammatory diseases is increasing, and pharmacologic agents for intervention are currently limited. Preserving epithelial tight junction (TJ) integrity and preventing underlying immune cell activation by intestinal bacteria are key targets for abrogating the perpetual inflammatory cycle that plagues these diseases. Phytonutrients have shown promise for their ability to reduce cellular inflammation, but the extent of their efficacy in an intestinal model of inflammation is not well understood. Here, we hypothesized that S7, a novel phytonutrient derived from extracts rich in curcuminoids and catechins, would reduce immune cell inflammation and preserve TJ integrity in an in vitro …
Study Of Alpha Mangostin As A Chemoprotective Agent For Breast Cancer Via Activation Of The P53 Pathway, Vanessa Van Oost
Study Of Alpha Mangostin As A Chemoprotective Agent For Breast Cancer Via Activation Of The P53 Pathway, Vanessa Van Oost
Honors Program Projects
Breast carcinoma is the most frequently diagnosed cancer among women and causes over 400,000 deaths each year worldwide. Current treatments such as chemotherapy are not selective for cancerous tissues but are destructive to normal tissues as well. This causes a range of side effects including pain, nausea, hair loss, weakness, and more. Inactivation of p53 is a very common mutation within human cancer cells. The ability to activate the p53 pathway which protects cells from tumor formation is lost in 50% of cancers. Due to the prevalence of this mutation, p53 is a uniquely valuable target for applied research. Alpha …
Exploring The Effects Of Protein Kinase C-Alpha Gene Knockout On The Proliferation Of Human Embryonic Kidney Cells, Emma J. Kuntz
Exploring The Effects Of Protein Kinase C-Alpha Gene Knockout On The Proliferation Of Human Embryonic Kidney Cells, Emma J. Kuntz
Honors Program Projects
Signaling molecules have important roles in many cellular functions, but because these pathways are incredibly complex, the exact mechanisms often remain unknown. One signaling molecule, protein kinase C alpha (PKCa), is involved in cell proliferation and is expressed at high levels in many cancers. Interestingly, its activity as a tumor promoter or tumor suppressor varies depending on the cell type for reasons not yet fully understood. This study aimed to investigate the role of PKCa in cell proliferation in order to better understand its function as a signaling molecule. To asses this, a knockout line was generated using CRISPR-Cas9 and …
Hexavalent Chromium: Elucidating Its Carcinogenic Mechanism, And Testing Potential Preventative Treatments, Ryan Himes, Timothy Mayotte
Hexavalent Chromium: Elucidating Its Carcinogenic Mechanism, And Testing Potential Preventative Treatments, Ryan Himes, Timothy Mayotte
Scholar Week 2016 - present
Cr(VI) (hexavalent chromium) has recently been found in the drinking water of over 250 million Americans. It is a powerful oxidizing agent, and is known to cause cancer, although the specific mechanism has yet to be elucidated. There is no known preventative treatment for Cr(VI) exposure, and the US EPA is currently determining what concentration of Cr(VI) in drinking water can be safely tolerated. This study sought to test the hypothesis that Cr(VI) cytotoxicity can be prevented by various antioxidants. We tested this hypothesis by exposing human embryonic kidney and human intestinal epithelial cells to Cr(VI), with and without the …
Alpha Mangostin As A Chemoprotective Agent Via Activation Of The P53 Pathway For Breast Cancer, Vanessa Van Oost
Alpha Mangostin As A Chemoprotective Agent Via Activation Of The P53 Pathway For Breast Cancer, Vanessa Van Oost
Scholar Week 2016 - present
Breast carcinoma is the most frequently diagnosed cancer among women and causes over 400,000 deaths yearly worldwide. Current treatments such as chemotherapy are not selective for cancerous tissues but are destructive to normal tissues as well. This causes a range of side effects including pain, nausea, hair loss, weakness, and more. Inactivation of p53 is an almost universal mutation within human cancer cells. The ability to activate the p53 pathway which protects cells from tumor formation is lost in 50% of cancers. Due to the prevalence of this mutation, p53 is a uniquely valuable target for applied research. Alpha mangostin …