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Full-Text Articles in Cell and Developmental Biology
Investigating The Role Of Dachshund Homolog 1 (Dach1) And Mir-200b In Group 4 Medulloblastoma Pathogenesis, Courtney George
Investigating The Role Of Dachshund Homolog 1 (Dach1) And Mir-200b In Group 4 Medulloblastoma Pathogenesis, Courtney George
Theses : Honours
Medulloblastoma is the most common malignant childhood brain tumour, and the most significant cause of childhood cancer-related mortality. Recently four core molecular medulloblastoma sub-groups have been identified, with distinct pathogenesis and responses to therapies. Current therapies, do not account for this molecular variation, and many patients may receive inappropriate treatment. To address this, targeted therapies for each molecular sub-group would be ideal. Unfortunately, for the more aggressive Group 3 and Group 4 subgroups, the underlying mechanisms of pathogenesis remain poorly understood. The current challenge is to identify the key tumour suppressors or oncogenes involved in Group 3 and Group 4 …
The Effects Of Oxidative Stress And Age On Human Spermatozoa, Taryn Mcandrew
The Effects Of Oxidative Stress And Age On Human Spermatozoa, Taryn Mcandrew
Theses : Honours
Male infertility is now recognised as a significant factor in couples having difficulty conceiving. The impact of maternal age has long been known as a limiting factor, however recent research indicates that advancing paternal age can also negatively impact on a couple's chances of conception. One of the major contributing causes of male infertility has now been linked to spermatozoa exposure to reactive oxygen species (ROS). Such exposure induces oxidative stress when coupled with reduced total antioxidant capacity (TAC). Measures of both ROS and TAC are used as tests of oxidative stress status (OSS) which are used together to give …