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A Novel Gain Of Function Of The Irx1 And Irx2 Genes Disrupts Axis Elongation In The Araucana Rumpless Chicken, Nowlan Freese
A Novel Gain Of Function Of The Irx1 And Irx2 Genes Disrupts Axis Elongation In The Araucana Rumpless Chicken, Nowlan Freese
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Caudal dysplasia describes a range of developmental disorders that affect normal development of the lumbar spinal column, sacrum and pelvis. An important goal of the congenital malformation field is to identify the genetic mechanisms leading to caudal deformities.
To identify the genetic cause(s) and subsequent molecular mechanisms I turned to an animal model, the rumpless Araucana chicken breed. Araucana fail to form vertebrae beyond the level of the hips. I performed a genome wide association study to identify candidate genomic regions associated with the rumpless phenotype, compared to tailed Araucana. A candidate region of chromosome 2 containing just two genes, …