Open Access. Powered by Scholars. Published by Universities.®
Cell and Developmental Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Acute Disease (1)
- Adaptor Proteins, Signal Transducing (1)
- Adaptor protein (1)
- Apoptosis (1)
- Biomarkers (1)
-
- Bronchopulmonary dysplasia (1)
- Cell cycle (1)
- Cell growth (1)
- Cytokines (1)
- Cytoplasm (1)
- Extracellular Matrix (1)
- Fibroblast (1)
- Fibroblast Growth Factor 2 (1)
- Fibroblasts (1)
- G1 Phase (1)
- Gene Knockdown Techniques (1)
- Growth factor (1)
- Humans (1)
- Lipopolysaccharides (1)
- Membrane Glycoproteins (1)
- Mitogen-Activated Protein Kinase Kinases (1)
- NADPH Oxidase 2 (1)
- NADPH Oxidases (1)
- NF-kappa B (1)
- Neonatal lung injury (1)
- Nicotinamide adenine dinucleotide phosphate oxidase (1)
- Nuclear Proteins (1)
- Pneumonia (1)
Articles 1 - 2 of 2
Full-Text Articles in Cell and Developmental Biology
Fibroblast Growth Requires Ct10 Regulator Of Kinase (Crk) And Crk-Like (Crkl)., Taeju Park, Mateusz Koptyra, Tom Curran
Fibroblast Growth Requires Ct10 Regulator Of Kinase (Crk) And Crk-Like (Crkl)., Taeju Park, Mateusz Koptyra, Tom Curran
Manuscripts, Articles, Book Chapters and Other Papers
CT10 regulator of kinase (Crk) and Crk-like (CrkL) are the cellular counterparts of the viral oncogene v-Crk Elevated levels of Crk and CrkL have been observed in many human cancers; inhibition of Crk and CrkL expression reduced the tumor-forming potential of cancer cell lines. Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL contribute to cell growth is unclear. We ablated endogenous Crk and CrkL from cultured fibroblasts carrying floxed alleles of Crk and CrkL by transfection with synthetic Cre mRNA (synCre). Loss of Crk and CrkL induced by synCre transfection blocked cell proliferation …
Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates Lps-Induced Inflammation And Alveolar Remodeling In The Developing Lung., Heather Menden, Sheng Xia, Sherry M. Mabry, Angels Navarro, Michael F. Nyp, Venkatesh Sampath
Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates Lps-Induced Inflammation And Alveolar Remodeling In The Developing Lung., Heather Menden, Sheng Xia, Sherry M. Mabry, Angels Navarro, Michael F. Nyp, Venkatesh Sampath
Manuscripts, Articles, Book Chapters and Other Papers
In premature infants, sepsis is associated with alveolar simplification manifesting as bronchopulmonary dysplasia. The redox-dependent mechanisms underlying sepsis-induced inflammation and alveolar remodeling in the immature lung remain unclear. We developed a neonatal mouse model of sepsis-induced lung injury to investigate whether nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) regulates Toll-like receptor (TLR)-mediated inflammation and alveolar remodeling. Six-day-old NOX2