Cell and Developmental Biology Commons^™

Ppar Agonists Down-Regulate The Expression Of Atp10c Mrna During Adipogenesis, A Peretich, Maria Cekanova Ms, Rndr, Phd, S Hurst, Sj Baek, Madhu Dahr

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

No abstract provided.

Morphogenesis Signaling Components Influence Cell Cycle Regulation By Cyclin Dependent Kinase, Brian Td Tobe, Ana A. Kitazono, Jacqueline S. Garcia, Renee A. Garber, Brooke J. Bevis, John S. Choy, Daniel Chasman, Stephen J. Kron

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

Background

The yeast cell cycle is largely controlled by the cyclin-dependent kinase (CDK) Cdc28. Recent evidence suggests that both CDK complex stability as well as function during mitosis is determined by precise regulation of Swe1, a CDK inhibitory kinase and cyclin binding partner. A model of mitotic progression has been provided by study of filamentous yeast. When facing nutrient-limited conditions, Ras2-mediated PKA and MAPK signaling cascades induce a switch from round to filamentous morphology resulting in delayed mitotic progression.

Results

To delineate how the dimorphic switch contributes to cell cycle regulation, temperature sensitive cdc28 mutants exhibiting constitutive filamentation were subjected …