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Full-Text Articles in Cell and Developmental Biology
The Effect Of Ethanolic Echinacea Purpurea Root Extracts On The Production Of Pro-Inflammatory Mediators In Raw 264.7 Murine Macrophages, Trey T. Nguyen
The Effect Of Ethanolic Echinacea Purpurea Root Extracts On The Production Of Pro-Inflammatory Mediators In Raw 264.7 Murine Macrophages, Trey T. Nguyen
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Echinacea purpurea, commonly known as the purple coneflower, is utilized in medicinal preparations due to potential immunostimulatory and anti-inflammatory properties. Present bioactive metabolites such as alkamides, polysaccharides, and caffeic acid derivatives provide pharmacological elements essential to mitigating symptoms produced by upper respiratory illnesses. The chemical composition of E. purpurea holds medicinal value, but there remains controversy surrounding the efficacy of its use in medicine. The purpose of this study is to examine the effects of an 75% ethanolic E. purpurea root extract on LPS (lipopolysaccharide)-stimulated RAW 264.7 murine macrophages. Treatment groups included ethanolic E. purpurea extract (3µL, 15µL, 30µL), …
Sirna Knock-Down Of Vav1 In Breast Cancer Cells: Effects On Pi3kinase And Akt, Tajai Sion-Milligan
Sirna Knock-Down Of Vav1 In Breast Cancer Cells: Effects On Pi3kinase And Akt, Tajai Sion-Milligan
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One in eight women in the United States will be diagnosed with breast cancer. Approximately 25-30% of these breast tumors will overexpress Human Epidermal Growth Factor Receptor 2 (HER2), associated with a worse prognosis and decreased survival rate. Stimulation of HER2 results in activation and production of many signaling molecules, ultimately resulting in increased cell division. Two of the downstream molecules activated are PI3Kinase and, further downstream, the molecule Akt. Typically, overproduction and/or overactivation of PI3Kinase can lead to oncogenesis. A molecule that may have a significant role in PI3Kinase formation is VAV1. VAV1 …
C-Myc’S Role On Methylation Of The Gata-2 Gene In Non-Small Cell Lung Carcinoma, Jonathan D. Hajduk
C-Myc’S Role On Methylation Of The Gata-2 Gene In Non-Small Cell Lung Carcinoma, Jonathan D. Hajduk
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Lung cancer accounts for more deaths per year than any other form of cancer, resulting in a total of 158,000 deaths per year in the U.S. Non-small cell lung cancer (NSCLC) is diagnosed in greater than 224,000 Americans every year. Methylation and subsequent downregulation of certain genes has been directly linked to the uncontrolled growth of NSCLC cells. Natural killer (NK) cells are key innate immune cells responsible for apoptosis of cells with incorrect genetic code. It is believed that one component of uncontrolled NSCLC growth is due to the NK cells’ inability to detect errors within NSCLC cells. Perhaps …