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- Keyword
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- A process termed mechanotransduction. Through cell-ECM focal adhesions (1)
- Aid in the advancement of both tissue engineering and cancer treatment research. (1)
- And polyacrylamide gels containing fluorescent beads. The mobility of integrin on the different substrates was assessed using fluorescent recovery after photo-bleaching (FRAP) and analyzed along with cell traction force measurements. These studies serve to further the understanding of our knowledge of integrin and its role in mechanotransduction and migration. It will (1)
- AngiognesisThe formation of new vasculature is an essential process (1)
- Breast cancer (1)
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- But can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin (1)
- Dense tissue (1)
- Early detection (1)
- Focal adhesion (1)
- Image-based risk assessment (1)
- Integrin (1)
- Integrin mediates the signaling both into and out of the cell (1)
- Mechanotransduction (1)
- Polydimethylsiloxane (PDMS) micro pillars (1)
- Promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force (1)
- Therefore (1)
- Visualization tool (1)
- We observed cells on three different substrates: polyacrylamide gels (1)
- Which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal (1)
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Cell and Developmental Biology
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
Electronic Theses and Dissertations
Breast cancer is the second most occurring cancer type and is ranked fifth in terms of mortality. X-ray mammography is the most common methodology of breast imaging and can show radiographic signs of cancer, such as masses and calcifcations. From these mammograms, radiologists can also assess breast density, which is a known cancer risk factor. However, since not all dense tissue is cancer-prone, we hypothesize that dense tissue can be segregated into healthy vs. risky subtypes. We propose that risky dense tissue is associated with tissue microenvironment disorganization, which can be quantified via a computational characterization of the whole breast …
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
Honors College
The formation of new vasculature is an essential process, but can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin, which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal, a process termed mechanotransduction. Through cell-ECM focal adhesions, integrin mediates the signaling both into and out of the cell, promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force, we …