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Full-Text Articles in Cell and Developmental Biology
A Chemical Genetics Approach To Understand The Regulation Of Cryptosporidium Sexual Differentiation, Md Mahmudul Hasan
A Chemical Genetics Approach To Understand The Regulation Of Cryptosporidium Sexual Differentiation, Md Mahmudul Hasan
Graduate College Dissertations and Theses
Cryptosporidium species are eukaryotic intracellular parasites belonging to the phylum Apicomplexa. C. hominis and C. parvum cause diarrhea in humans which is self-limiting in immunocompetent adults but can have severe consequences in immunocompromised individuals and malnourished children. In developing countries, Cryptosporidium is one of the leading causes of moderate to severe diarrhea in children under five years of age. There is an urgent need for novel therapeutics against this parasite as the current treatment option is inadequate to treat the most vulnerable population to Cryptosporidium infection. Better understandings of the biology of Cryptosporidium would greatly enhance our capability to design …
Pathological Consequences Of Pdi Oxidoreductase Activity On Viral Protein Maturation, Nicolas Chamberlain
Pathological Consequences Of Pdi Oxidoreductase Activity On Viral Protein Maturation, Nicolas Chamberlain
Graduate College Dissertations and Theses
The influenza A virus (IAV) causes severe respiratory illness in humans. Current treatments are rapidly becoming ineffective due to the emergence of viral resistance to available therapies such as oseltamivir and zanamivir. Given the impact of this virus there is an urgent need to explore novel targets for new treatments less susceptible to viral mutation; targeting host proteins utilized by the virus may avoid these limitations. It has been shown in vitro that interactions with host ER based protein disulfide isomerases (PDIs) are required for specific IAV proteins to reach their functional conformations. The viral proteins hemagglutinin (HA) and neuraminidase …