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Articles 1 - 15 of 15
Full-Text Articles in Cell and Developmental Biology
Functional Analysis Provides Insight Into Missing Heritability, Scott L. Baughan, Michael A. Tainsky, Fatima Darwiche
Functional Analysis Provides Insight Into Missing Heritability, Scott L. Baughan, Michael A. Tainsky, Fatima Darwiche
Medical Student Research Symposium
Accurate ascertainment of genetic risk can be potentially lifesaving for patients who inherit cancer promoting mutations. However, even with the most extensive panel testing clinically available, a large number of patients will test negative despite family history of cancer or test positive for a variant of unknown significance (VUS). For these patients, clinical management is complicated; patients want to know their risk, and may fear disease they are not at great risk for (benign VUS) or they may not be given access to potentially lifesaving early screening procedures (pathogenic VUS). ATM has proven a challenge to clinicians due to its …
Investigating Respiratory Simplification Caused By Prenatal Rage Upregulation, Paul Reynolds
Investigating Respiratory Simplification Caused By Prenatal Rage Upregulation, Paul Reynolds
Annual Research Symposium
No abstract provided.
Potential Role For Rage In The Development Of Secondhand Smoke-Induced Chronic Sinusitis, Paul Reynolds
Potential Role For Rage In The Development Of Secondhand Smoke-Induced Chronic Sinusitis, Paul Reynolds
Annual Research Symposium
No abstract provided.
Rage Inhibition Reduces Timp And Decreases Cell Invasion In Cigarette Smoke Extract (Cse) Treated Oral Squamous Carcinoma Cells, Paul Reynolds
Rage Inhibition Reduces Timp And Decreases Cell Invasion In Cigarette Smoke Extract (Cse) Treated Oral Squamous Carcinoma Cells, Paul Reynolds
Annual Research Symposium
No abstract provided.
Rage Availability Lessens The Degree Of Dysfunctional Mitochondrial Bioenergetics Following Chronic Secondhand Smoke Exposure, Paul Reynolds
Rage Availability Lessens The Degree Of Dysfunctional Mitochondrial Bioenergetics Following Chronic Secondhand Smoke Exposure, Paul Reynolds
Annual Research Symposium
No abstract provided.
Gestational Dependent Responses To Second Hand Smoke (Shs) In Mouse Pregnancies, Paul Reynolds
Gestational Dependent Responses To Second Hand Smoke (Shs) In Mouse Pregnancies, Paul Reynolds
Annual Research Symposium
No abstract provided.
Influence Of Myelin-Associated Glycoprotein On Axon Subtype Specific Sheath Targeting, Nazmus Sakib Khan
Influence Of Myelin-Associated Glycoprotein On Axon Subtype Specific Sheath Targeting, Nazmus Sakib Khan
Ramaley Celebration
During the development of the Central Nervous System, oligodendrocytes wrap axons with myelin, which is necessary for rapid, efficient nerve impulse propagation. For reasons unknown, oligodendrocytes direct myelin to certain subtypes of axons, leaving others incompletely myelinated, or even totally unmyelinated. Previous studies demonstrated mice harboring Mag mutations showed improper sheath targeting of myelin to axons indicating that MAG is a possible facilitator of axon-glia communication.
In the present study, we tested the hypothesis that loss of mag decreases the proportion of myelin directed towards specific axon subtypes. To test this, we perturbed Mag function in zebrafish embryos using knockdown …
Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp
Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp
Yale Day of Data
This poster illustrates the differences between the IPF disease-specific variety of lung macrophages and the two varieties of macrophages known to reside in the normal human lung.
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Posters-at-the-Capitol
Immunotherapy strategies are very promising treatments for cancer patients. Specifically, Immune checkpoint inhibitor therapy focusing on the PD-1/PD-L1 pathway shows long-lasting positive results in many cancer patients. Unfortunately, not all the patients can benefit from this highly effective treatment. Hence, there is a great need for predictive biomarkers. Immunohistochemical (IHC) staining has been used as a way of predicting patient response, yet shows many problems. For example, IHC utilizes an invasive biopsy and sample fixing, which creates an incomplete and delayed picture of the patient’s biochemistry and the tumor microenvironment, consequently ignoring metastases.
The purpose of this study is to …
Sirna Knock-Down Of Vav1 In Breast Cancer Cells: Effects On Pi3kinase And Akt, Tajai Sion-Milligan
Sirna Knock-Down Of Vav1 In Breast Cancer Cells: Effects On Pi3kinase And Akt, Tajai Sion-Milligan
Student Scholar Showcase
One in eight women in the United States will be diagnosed with breast cancer. Approximately 25-30% of these breast tumors will overexpress Human Epidermal Growth Factor Receptor 2 (HER2), associated with a worse prognosis and decreased survival rate. Stimulation of HER2 results in activation and production of many signaling molecules, ultimately resulting in increased cell division. Two of the downstream molecules activated are PI3Kinase and, further downstream, the molecule Akt. Typically, overproduction and/or overactivation of PI3Kinase can lead to oncogenesis. A molecule that may have a significant role in PI3Kinase formation is VAV1. VAV1 …
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Andrews Research Conference
Streptococcus mutans JH1140 is a strain of bacteria which produces a lantibiotic product, named mutacin 1140. Mutacin 1140 has been shown to be effective at inhibiting Gram-positive bacterial infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Mutacin 1140 is a ribosomally synthesized peptide antibiotic that undergoes extensive posttranslational modifications (PTM). We have found that Mutacin 1140 and an aminoglycoside, Kanamycin, when combined together, act synergistically against Staphylococcus aureus. This was determined by performing serial kill curve dilution overlays on solid media, followed up with kill curve by microdilution plate, and most recently confirmed with kill curve CFU count plates …
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Maxine G Schmidt
Presentation delivered to librarians in China, Japan and South Korea as part of my sabbatical research on the use of libraries by Asian students in their home countries.
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.
Umass Libraries 2009, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.